- 期刊
Diethylmaleate Decreased Ascorbic Acid Release Induced by Cerebral Ischemia in Cerebral Cortex of the Anesthetized Rat
並列摘要
The effect of diethylmaleate administration on ascorbic acid release following cerebral ischemia was investigated in anesthetized rat brain cortex. Cerebral ischemia, induced by ligating bilateral common carotid arteries and unilateral middle cerebral artery, significantly increased the extracellular ascorbic acid levels. Diethylmaleate (4 mmoles/kg, i.p.), which has been shown in earlier studies to decrease the ischemia-induced glutamate release, significantly reduced the ischemia-induced ascorbic acid release. The ischemia-induced ascorbic acid release was unaffected by perfusing NMDA receptor antagonist MK 801 (75μM). Additionally, elevated extracellular glutamate levels, achieved by either externally applied glutamate solutions or by perfusing L-trans-pyrrolidine-2,4-dicarboxylate (PDC) (31.4mM and 15.7mM) to inhibit the glutamate uptake transporter, also significantly increased the extracellular ascorbic acid levels. These results suggested that ascorbic acid release in cerebral ischemia might be related to the elevated extracellular glutamate levels, which occurs following cerebral ischemia.
延伸閱讀
- Huang, T. F. (1992). Drug Effects on the Ischemia-and Reperfusion-Induced Arrhythmias in the Conscious Rats. The Chinese Journal of Physiology, 35(1), 9-19. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199203-35-1-9-19-a
- 吳國任、吳啓瑞、蔡汎修、林立偉、呂宗俊、王文信、彭文煌、謝明村（2005）。Effects of Theae Folium Extract on Cerebral Ischemia-induced Memory Impairment in Rats。Mid-Taiwan Journal of Medicine，10(s)，s9-s15。https://doi.org/10.6558/MTJM.2005.10(s).2
- Ghorbani, A., Nick, R. S., Rakhshandeh, H., & Borji, A. (2013). Antihyperlipidemic Effect of a Polyherbal Mixture in Streptozotocin-Induced Diabetic Rats. Journal of Lipids, 2013(), 115-120. https://doi.org/10.1155/2013/675759
- Chen, S. (2002). Role of neuropeptide Y and its receptor analogues in focal cerebral ischemia in the rat [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200015594
- Yen, M. H., & Lee, S. H. (1990). Effects of Lipoxygenase Inhibitor on Cerebral Edema Induced by Freezing Lesion in Rats. The Chinese Journal of Physiology, 33(4), 385-397. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199012-33-4-385-397-a