- 期刊
The Effect of Bicuculline Application on Auditory Response Properties of Inferior Collicular Neurons of Mice with or Without Monaural Middle Ear Destruction in Early Age
並列摘要
Previous studies have demonstrated that abnormal auditory stimulation during early postnatal development can be manifested through physiological changes that occur in the inferior colliculus (IC) of mammals. To determine the contribution of the GABAergic transmitter systems to the development of response properties of IC neurons, we examined the effect of application of bicuculline (which is an antagonist for the GABA(subscript A) receptors) on response properties of IC neurons of the laboratory mice, Mus musculus, with or without early monaural middle ear destruction. Monaural middle ear destruction was performed at 12-14 days after birth. At adulthood, the auditory response properties of IC neurons were examined in both experimental conditions. All IC neurons determined before and during bicuculline application can be described as (1) phasic responders which discharged 1-2 impulses; (2) phasic bursters which discharged 3-7 impulse; and (3) tonic responders which discharged impulses throughout the duration of presented sound pulses. Early monaural middle ear destruction only affected the percent distribution but not the type of discharge pattern, rate-intensity function and frequency tuning curve of IC neurons in the control and experimental mice. Neurons in the contralateral IC of experimental mice typically had longer latencies, higher minimum thresholds, broader frequency tuning curves and smaller dynamic ranges than neurons in the ipsilateral IC and in control mice. Bicuculline application produced differential effects in decreasing the latencies and minimum thresholds as well as broadening frequency tuning curves and dynamic ranges of IC neurons in these two groups of mice. All these data suggest that early monaural middle ear destruction did not affect the shaping of auditory response properties of IC neurons by GABAergic transmitter system.
延伸閱讀
- Law, H. Y. (2001). Immunocytochemical study of the developmental profile of glutamate receptor subunits in otolith neurons of the rat vestibular nucleus [master's thesis, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200006063
- 鍾欣芸（2015）。Effect of docosahexaenoic acid on retinoic acid-induced neurite outgrowth and neuronal protein expression in human neuroblastoma SH-SY5Y cell line and the developing rats〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2015.10646
- Hsieh, Y. L., Chen, S. S., & Chen, T. J. (1998). The Suppressive Effect of the Olivocochlear Bundle in Rats Studied by Brainstem Auditory Evoked Potentials Following Brainstem Lesion. The Kaohsiung Journal of Medical Sciences, 14(11), 679-690. https://doi.org/10.6452/KJMS.199811.0679
- Gumuslu, E., Mutlu, O., Kokturk, S., Ulak, G., Eraldemir, F. C., Tatar, O. C., Yasar, A. B., Tanyeri, P., Akar, F., & Erden, F. (2018). Effects of Asenapine and Paliperidone on Depression, Anxiety and Analgesy in Mice: Alterations in Brain Neurotrophic Factors, Neurogenesis, and Blood Enzyme Levels. The Chinese Journal of Physiology, 61(5), 280-292. https://doi.org/10.4077/CJP.2018.BAH626
- Wu, Y. C. (2011). The effect of ascorbic acid and α-tocopherol supplement on the responses of rats and their nucleus tractus solitarius neurons to hypobaric hypoxia [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2011.02014