Alteration of Cardiovascular Autonomic Functions by Vegetarian Diets in Postmenopausal Women is Related to LDL Cholesterol Levels

Chin-Hua Fu ； Cheryl C. H. Yang ； Chin-Lon Lin ； Terry B. J. Kuo

《The Chinese Journal of Physiology》 51卷2期 (2008/04) Pp. 100-105

並列摘要

This study was designed to test the hypothesis that alteration of cardiovascular autonomic functions by vegetarian diets in healthy postmenopausal women is related to lipid metabolism. A total of 70 healthy postmenopausal women not on hormone therapy participated in this study: 35 were vegetarians (mean age 55.0 years) and 35 were omnivores (mean age 55.1 years). Cardiovascular autonomic functions and baroreflex sensitivity were evaluated by specific frequency-domain measures of heart rate variability (HRV) and arterial blood pressure fluctuation. The vegetarians had statistically significant lower blood pressure, total cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, and fasting glucose levels compared with the omnivores. The vegetarians exhibited a significant higher total power, low-frequency (LF; 0.04-0.15 Hz) and high-frequency (HF; 0.15-0.4 Hz) of HRV and increased baroreflex sensitivity measures [Brr(LF) and Brr(HF)] compared with the omnivores. Total power, LF and HF of HRV, Brr(LF), and Brr(HF) were significant negatively correlated to LDL-cholesterol concentrations (P ＜ 0.01). We conclude that the increases of cardiac vagal activity and baroreflex sensitivity by vegetarian diets in postmenopausal women are inversely related to LDL-cholesterol levels.

並列關鍵字

vegetarian diets ； postmenopausal women ； low-density lipoprotein ； coronary artery disease ； heart rate variability ； frequency-domain analysis

參考文獻

Banach, T.,Dobrek, L.,Milewicz, T.,Kolasinska-Kloch, K.,Krezysiek, J.,Thor, P.J.(2004).Effect of hormonal replacement therapy on autonomic regulation of the heart.Przegl. Lek..61,509-513.

Berliner, J.A.,Heinecke, J.W.(1996).The role of oxidized lipoproteins in atherogenesis.Free Radic. Biol. Med..20,707-727.

Carr, M.C.(2003).The emergence of the metabolic syndrome with menopause.J. Clin. Endocrinol. Metab..88,2404-2411.

Chowienczyk, P.J.,Watts, G.F.,Cockcroft, J.R.,Ritter, J.M.(1992).Impaired endothelium-dependent vasodilatation of forearm resistance vessels in hypercholesterolemia.Lancet.340,1430-1432.

Christensen, J.H.,Toft, E.,Christensen, M.S.,Schmidt, E.B.(1999).Heart rate variability and plasma lipids in men with and without ischemic heart disease.Atherosclerosis.145,181-186.