Neural Reflex Hypotension Induced by Very Small Dose of Hypertonic NaCl Solution in Rats

Although the precise mechanisms of transient hypotension after intravenous infusion of hypertonic saline (HTS) are not yet clarified, a rapid infusion of HTS is widely used as the initial therapy of hypovolemia. We investigated the effect of the intravenous infusion of a small dose of 0.97-9.7% NaCl solutions in anesthetized rats. Intravenous infusion of HTS at a rate of 0.3 ml/kg/min for 1 min produced the transient hypotension lasting for several minutes. The depressor response to HTS was not abolished by bilateral cervical vagotomy. The HTS infusion into the femoral vein evoked the depressor response with a larger magnitude and a shorter latency than that into the aortic arch. While the arterial baroreceptor pressure was kept constant at the baseline level of systemic arterial pressure, HTS-induced hypotension was significantly augmented. The gain factor of the arterial baroreflex was reduced by intravenous HTS. Pretreatment with bretylium tosylate completely abolished the depressor response without affecting the baseline level of arterial pressure. These results suggest that the depressor response to the very small dose of intravenous HTS is the sympathosympathetic neural reflex with cardiopulmonary afferents and vasomotor efferents.

並列關鍵字

arterial pressure ； baroreflex ； hypotension ； osmolality

參考文獻

Antunes, V.R.,Yao, S.T.,Pickering, A.E.,Murphy, D.,Paton, J.E.(2006).A spinal vasopressinergic mechanism mediated by hyperos-molality-induced sympathoexcitation.J. Physiol..576,569-583.

Google Scholar

Conway, J.,Lauwers, P.,Hoobler, S.W.(1961).A sympathetic blocking agent, bretylium tosylate (Darenthin), in the treatment of hypertension.J. Lab. Clin. Med..57,199-205.

Google Scholar

Holland, R.C.,Sundsten, J.W.,Sawyer, C.H.(1959).Effects of intracarotid injections of hypertonic solutions on arterial pressure in the rabbit.Circ. Res..7,712-720.

Google Scholar

Kabashi, M.,Adachi, A.(1995).Chemosensitivity of neurons in the dorsal motor nucleus of the vagus that responded to portal infusion of hypertonic saline in rats.Brain Res. Bull..38,11-15.

Google Scholar

Kreimeier, U.,Messmer, K.(2002).Small-volume resuscitation: from experimental evidence to clinical routine. Advantages and disadvantages of hypertonic solutions.Acta Anaesthesiol. Scand.46,625-638.

Google Scholar

被引用紀錄

許家瑋（2016）。利用X光散射研究IrTe2中電荷調制結構的一階相變〔碩士論文，淡江大學〕。華藝線上圖書館。https://doi.org/10.6846/TKU.2016.00874

周貝倫（2006）。純化程序對奈米碳管表面特性影響之研究〔碩士論文，國立中央大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0031-0207200917342544

延伸閱讀

游妙娟（2008）。Inhalation Toxicity of Ultrafine Zinc Oxide Particles in Spontaneously Hypertensive Rats〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2008.00177
Lin, A. M. Y., Kuo, J. S., & Chai, C. Y. (1997). Paramedian Reticular Nucleus May be Unrelated to the Development of Hypertension in Spontaneously Hypertensive Rats. The Chinese Journal of Physiology, 40(2), 91-96. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199706-40-2-91-96-a
Sahoo, D. K., & Roy, A. (2012). Compromised Rat Testicular Antioxidant Defence System by Hypothyroidism before Puberty. International Journal of Endocrinology, 2012(), 661-671. https://doi.org/10.1155/2012/637825
Loh, C. H., Liao, M. T., Liu, T. T., Chang, B. C., & Hsieh, P. S. (2006). Short-Term Infusion of a Triglyceride Emulsion Induces a Long-Lasting Pressor Response in Rats. Journal of Medical Sciences, 26(6), 205-210. https://www.airitilibrary.com/Article/Detail?DocID=10114564-200612-201303260011-201303260011-205-210
陳吉麟（2016）。Stimulation system for rat whisker and functional recovery after infraorbital nerve transection〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU201610144

國際替代計量

Neural Reflex Hypotension Induced by Very Small Dose of Hypertonic NaCl Solution in Rats

全文下載

主題瀏覽