- 期刊
Male Sexual Behavior and Brain Catecholamine Levels in Middle-Aged Rats
並列摘要
During aging, increased qualitative variations in copulatory behavior are observed in male rats. At the age of 18-19 months, only a small proportion of male rats (16%) still display the complete mating behavior, including mounts, intromissions, and ejaculations, but the rest of these middle-aged animals (84%) fail to exhibit one, two or all of the three behavioral components. With distinct behavioral phenotypes, the middle-aged male rats provide us a useful animal model to investigate the neuroendocrine mechanisms responsible for the age-related reduction in sexual behavior. We have previously elucidated the correlation between the loss of specific copulatory behavioral components and tissue levels of catecholamines in the medial preoptic area (MPOA), nucleus accumbens (NAc) and the bed nucleus of stria terminalis (BNST) of middle-aged male rats. Thus, our findings not only demonstrate that levels of dopamine and norepinephrine in the MPOA, NAc and BNST are critical for eliciting copulatory behavior, but also suggest that these two neurotransmitters play distinct roles in different brain regions to control specific behavioral components in male rats.
參考文獻
延伸閱讀
- Pi, W. P., & Lin, C. H. (1993). Effects of Monoamine Precursors on Food Intake in Male Rats. The Chinese Journal of Physiology, 36(3), 171-176. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199309-36-3-171-176-a
- Lau, W. M. (2009). Study of adult neurogenesis and molecular mechanism underlying sexual behavior in male rats following induction of depression-like behaviorand pharmacological treatment [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200015243
- AM, M., O, S., HM, E. H., & AF, A. S. (2018). Deterioration of Brain Cell Function Induced by Dapoxetine Administration in Male Rats. International Journal of Clinical Pharmacology & Toxicology (IJCPT), 7(1), 284-289. https://doi.org/10.19070/2167-910X-1800047
- Chang, S. T., Tung, C. S., Lin, Y. L., Chuang, C. H., Lee, A. R., & Liu, Y. P. (2010). Behavioral and Cross Sensitization after Repeated Exposure to Modafinil and Apomorphine in Rats. The Chinese Journal of Physiology, 53(5), 318-327. https://doi.org/10.4077/CJP.2010.AMK067
- 卓宜興、梁鍾鼎、林裕翔、陳錦富、曾彥勳、廖秀鈴、梁善居、黃彥智（2009）。Retrospective Study of Spontaneous Lesions in the Germfree Mice and Rats。臺灣獸醫學雜誌，35(2)，124-130。https://doi.org/10.7009/TVJ.200906.0124