State-Dependent Amygdala Stimulation-Induced Cardiovascular Effects in Rats

Ruei-Jen Chiou ； Chung-Chih Kuo ； Keng-Chen Liang ； Chen-Tung Yen

《The Chinese Journal of Physiology》 52卷6期 (2009/12) Pp. 432-440

https://doi.org/10.4077/CJP.2009.AMH046

並列摘要

Stimulation of the amygdala is known to produce pressor, depressor, or has no effects. The present study was performed to test whether amygdala cardiovascular effects are influenced by consciousness states and by different types of anesthetics. Adult rats were set up for stimulation amygdala and measurement of blood pressure in a chronic preparation. After recovery, same sites of the amygdala were stimulated electrically for several trials with the rat under conscious or anesthetic states induced by pentobarbital, urethane, ketamine, α-chloralose and urethane plus α-chloralose, respectively. The interval between any two stimulation trials was at least 2 days. The stimulation was an 80-Hz, 0.5-ms, 100-μA square wave pulse train lasting for 15 s. Cardiovascular responsive sites were found in the central, medial, and basolateral nuclei of the amygdala. In stimulating these responsive sites, significantly different cardiovascular effects were induced under a conscious state and an anesthetized state of the animal, yet no significant differences were found among the various anesthetic agents. We conclude, that the cardiovascular influence of the amygdala is state-dependent in the rat.

並列關鍵字

amygdale ； anesthesia ； blood pressure ； heart rate ； electrical stimulation ； ketamine ； pentobarbital ； chloralose ； urethane

參考文獻

Altura, B.M.,Altura, B.T.,Carella, A.,Turlapaty, P.D.M.V.,Weinberg, J.(1980).Vascular smooth muscle and general anesthstics.Fed. Proc..39,1584-1591.

Cain, D.P.,Aggleton, J.P. (edited)(1992).Kindling and the Amygdala.New York:Wiley-Liss, Inc..

Campeau, S.,Davis, M.(1995).Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli.J. Neurosci..15,2301-2311.

Canli, T.,Sivers, H.,Whitfield, S.L.,Gotlib, I.H.,Gabrieli, J.D.E.(2002).Amygdala response to happy faces as a function of extraversion.Science.296,2191.

Ciriello, J.,Roder, S.(1999).Gabaergic effects on the depressor responses elicited by stimulation of central nucleus of the amygdala.Am. J. Physiol..276,242-247.