- 期刊
Involvement of NMDA Receptors in Nicotine-Mediated Central Control of Hypotensive Effects
並列摘要
It is known that enrichment of glutamatergic transmission in the nucleus tractus solitarii (NTS) plays an important role in central cardiovascular regulation. Our previous study demonstrated that nicotine decreased blood pressure and heart rate in the NTS probably acting via the nicotinic acetylcholine receptors (nAChRs)-Ca^2+ -calmodulin-eNOS-NO signaling pathway. The possible relationship between glutamate and nicotine in the NTS for cardiovascular regulation is poorly understood. This study investigated the involvement of glutamate receptors in the cardiovascular effects of nicotine in the NTS. Nicotine (a non-selective nAChRs agonist), MK801 (a non-competitive NMDA receptor antagonist), APV (a competitive NMDA receptor antagonist), or NBQX (a selective AMPA receptor antagonist) was microinjected into the NTS of anesthetized Wistar-Kyoto rats. Microinjection of nicotine (1.5 pmol) into the NTS produced decreases in blood pressure and heart rate. The hypotensive and bradycardic effects of nicotine were abolished by prior administration of MK801 (1 nmol) and APV (10 nmol), but was completely restored after 60 min of recovery. In contrast, prior administration of NBQX (10 pmol) into the NTS did not alter the cardiovascular effects of nicotine. The nitrate (served as total NO) production in response to nicotine microinjection into the NTS was suppressed by prior administration of APV. These results suggest that the hypotensive and bradycardic effects of nicotine in the NTS might be mediated through NMDA receptors, and that the nAChRs-NMDA receptor-NO pathway could be involved.
參考文獻
延伸閱讀
- Lin, C. H., Pan, J. Y., Chang, J. J., Chen, H. H., Cheng, P. W., & Tseng, C. J. (2013). Involvement of Endothelial Nitric Oxide Synthase Activation in Midkine-Mediated Central Hypotensive Effects. The Chinese Journal of Physiology, (), 1-10. https://doi.org/10.4077/CJP.2017.BAG512
- Lin, C. H., Pan, J. Y., Chang, J. J., Chen, H. H., Cheng, P. W., & Tseng, C. J. (2017). Involvement of Endothelial Nitric Oxide Synthase Activation in Midkine-Mediated Central Hypotensive Effects. The Chinese Journal of Physiology, 60(6), 353-362. https://doi.org/10.4077/CJP.2017.BAG512
- Ma, L. (2008). The influence of nicotine on angiogenesis and osteogenesis in bone regeneration [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200014960
- Sham, N. F. (2001). Study of the protective mechanisms of cigarette smoke and nicotine on experimental ulcerative colitis in rats [master's thesis, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200006430
- Liu, S. L. (2003). Pathogenic mechanisms of cigarette smoking on ulcerative colitis-associated neoplasia in mice [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200008137