- 期刊
- Ahead-of-Print
Spatiotemporal Changes of Neuronal Responses in the Primary Somatosensory Cortex to Noxious Tail Stimulation in Awake and Pentobarbital-Anesthetized Rats
並列摘要
Primary somatosensory cortex (SI) is a key area in the processing of nociceptor inputs to our consciousness. To clarify the columnar and laminar organization of SI for pain processing, we compared spatiotemporal changes in neuronal activities of the primary sensorimotor cortex (SmI) of the rat in response to noxious laser heat stimulation applied to the mid-tail. Longitudinal and vertical array microelectrodes were chronically implanted in the cerebral cortex. Evoked neuronal activities, including intracortical local field potentials (LFP) and ensemble single-unit activity (SU) around SmI were simultaneously recorded. The effect of pentobarbital on the neuronal responses was evaluated in comparison with the neuronal responses in conscious animals to explore the potential substrate of nociceptive processing in the conscious state. The results from the experiment with longitudinal microelectrode arrays indicated that noxious stimulation induced a neuronal response which was spread widely around the SmI of the conscious rat, and the range of neuronal responses was limited to the tail region of the SmI under anesthesia. The results from the experiment with vertical microelectrode arrays showed the universal neuronal responses through all cortical layers of the SmI in conscious rats, and sodium pentobarbital suppressed these neuronal responses in the supragranular layers significantly relative to the deeper layers and basal activity. These results imply that a wider range of cortical activation, both in the horizontal or vertical dimension, might be important for nociceptive processing in the conscious state.
延伸閱讀
- Lau, W. M. (2009). Study of adult neurogenesis and molecular mechanism underlying sexual behavior in male rats following induction of depression-like behaviorand pharmacological treatment [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200015243
- Savotchenko, A., Romanov, A., Isaev, D., Maximyuk, O., Sydorenko, V., Holmes, G. L., & Isaeva, E. (2015). Neuraminidase Inhibition Primes Short-Term Depression and Suppresses Long-Term Potentiation of Synaptic Transmission in the Rat Hippocampus. Neural Plasticity, 2015(), 466-475-141. https://doi.org/10.1155/2015/908190
- Ho, C. Y. (2005). Comparison of Physiological and Morphological Characteristics of Thalamic Reticular and Ventroposterior Lateral Neurons of the Rat [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2005.01982
- Tsai, W. L. (2008). The Relationship Between the Neural Signal of Primary Somatosensory Cortex and Tactile Stimuli of Hindlimb in Rats [master's thesis, National Taipei University of Technology]. Airiti Library. https://doi.org/10.6841/NTUT.2008.00549
- Chen, C. P. (2011). Nociceptive responses of the posterior thalamic nucleus to peripheral noxious stimuli in anesthetized rats [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2011.02232