- 期刊
- Ahead-of-Print
Serum Glutamine Levels as a Potential Diagnostic Biomarker in Sepsis following Surgery for Peritonitis
摘要
Few diagnostic biomarkers for sepsis after emergency peritonitis surgery are available to clinicians, and, thus, it is important to develop new biomarkers for patients undergoing this procedure. We investigated whether serum glutamine and selenium levels could be diagnostic biomarkers of sepsis in individuals recovering from emergency peritonitis surgery. From February 2012 to March 2013, patients who had peritonitis diagnosed at the emergency department and underwent emergency surgery were screened for eligibility. Serum glutamine and selenium levels were obtained at pre-operative, post-operative and recovery time points. The average level of pre-operation serum glutamine was significantly different from that on the recovery day (0.317 ± 0.168 vs. 0.532 ± 0.155 mM, P ＜ 0.001); moreover, serum glutamine levels were unaffected by surgery. Selenium levels were significantly lower on the day of surgery than they were at recovery (106.6 ± 36.39 vs. 130.68 ± 56.98 ng/mL, P = 0.013); no significant difference was found between pre-operation and recovery selenium levels. Unlike selenium, glutamine could be a sepsis biomarker for individuals with peritonitis. We recommend including glutamine as a biomarker for sepsis severity assessment in addition to the commonly used clinical indicators.
延伸閱讀
- Wu, H. P., Shih, C. C., Chuang, D. Y., & Chen, T. H. (2016). Low-Dose Steroid Therapy Is Associated with Decreased IL-12 Production in PBMCs of Severe Septic Patients. Mediators of Inflammation, 2016(), 333-340-031. https://doi.org/10.1155/2016/1796094
- Lentini, P., Cal, M. D., Clementi, A., D'Angelo, A., & Ronco, C. (2012). Sepsis and AKI in ICU Patients: The Role of Plasma Biomarkers. Critical Care Research and Practice, 2012(), 615-619. https://doi.org/10.1155/2012/856401
- Chen, Y. F., Cheng, Y. W., Yu, C. Y., Tseng, Y. H., Wu, Z. J., & Yu, K. H. (2015). Prevalence, Prognostic Factors, and Survival Analysis of Systemic Lupus Erythematosus-Related Serositis. Formosan Journal of Rheumatology, 29(1), 10-18. https://doi.org/10.6313/FJR.2015.29(01).02
- Koch, A., Weiskirchen, R., Bruensing, J., Dückers, H., Buendgens, L., Kunze, J., MichaelMatthes, Luedde, T., Trautwein, C., & Tacke, F. (2013). Regulation and Prognostic Relevance of Symmetric Dimethylarginine Serum Concentrations in Critical Illness and Sepsis. Mediators of Inflammation, 2013(), 306-313-128. https://doi.org/10.1155/2013/413826
- 簡榮彥（2004）。Association of Serum Lipoprotein and Apolipoprotein Levels with the Prognosis of Patients with Severe Sepsis〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2004.01475