- 期刊
- Ahead-of-Print
A Randomized, Double-Blind Clinical Study on Blood Pressure Reduction and Blood Lipid Profile Amelioration on Treatment with Ankascin 568
摘要
Hypertension and cardiovascular complications are the leading causes of death worldwide. Antihypertensive drugs often cause various side effects, and improper use of antihypertensive medications can result in irreparable damage. Edible fungi of the Monascus species have been used as traditional Chinese medicines in Southeast Asia for several centuries. The fermented products of Monascus purpureus NTU 568 (ANKASCIN 568) possess a number of functional secondary metabolites including the anti-inflammatory pigments monascin and ankaflavin. In this study, a double-blind, placebo-controlled clinical trial was performed in which patients with mild to moderate hypertension were randomly assigned to receive placebo or two 500-mg capsules of Ankascin 568 for 8 weeks. The effects of this treatment on the regulation of blood pressure were then examined. The results showed that systolic blood pressure decreased from 141.6 ± 12.0 to 133.9 ± 14.4 mmHg (P ＜ 0.05), and diastolic blood pressure decreased from 91.7 ± 8.1 to 84.8 ± 7.4 mmHg (P ＜ 0.05). Moreover, Ankascin 568 treatment effectively reduced serum triglycerides and total cholesterol, increased high-density lipoprotein cholesterol, and reduced low-density lipoprotein cholesterol (LDL-C) levels, thereby improving the serum lipid profile. Additionally, administration of Ankascin 568 did not cause significant rhabdomyolysis nor impaired the metabolic or physiological functions of the liver or kidney. In conclusion, patients administered Ankascin 568 for 8 weeks exhibited significant in systolic blood pressure and reduction in serum total cholesterol and LDL-C levels, which should contribute to better cardiovascular health.
延伸閱讀
- 羅嘉盈、王美廸、陳怡樺、陳玉瑩（2018）。Evaluation of the Clinical Efficacy of Prolonged Infusion in Preventing Recurrent Oxaliplatin-Induced Hypersensitivity Reactions。臺灣臨床藥學雜誌，26(1)，39-46。https://doi.org/10.6168/FJCP.201801_26(1).0005
- Chibisov, S., Katinas, G., Brodskaya, I., Ertman, A., Gromyko, G., Konradi, A., Mamontov, O., Merkuryeva, A., Polunicheva, E., Shlyakhto, E., Soboleva, A., Yashin, S., & Bhavdip, B. (2013). Chronobiological Analysis of Blood Pressure in a Patient with Atrial Fibrillation at the Development of Heart Failure and Its Therapeutic and Surgical Treatment. Cardiology Research and Practice, 2013(), 98-113. https://doi.org/10.1155/2013/490705
- Pai, P. Y., Chou, H. T., Tsou, S. S., Chen, C. C., & Wang, T. F. (1998). Diurnal Blood Pressure Changes in Primary Aldosteronism- A Study of Ambulatory Blood Pressure Monitoring and Neurohormonal Changes. Mid-Taiwan Journal of Medicine, 3(1), 27-33. https://doi.org/10.6558/MTJM.1998.3(1).5
- Lu, T. D., Kao, C. H., & Lee, C. C. (2003). Brain SPECT on Regional Cerebral Blood Flow to Objectively Evaluate the Therapy Effects of Anticoagulant in Patients with Primary Antiphospholipid Antibody Syndrome. Mid-Taiwan Journal of Medicine, 8(Commemorative), 305-310. https://doi.org/10.6558/MTJM.2003.8(C).8
- Malacco, E., Omboni, S., & Parati, G. (2015). Blood Pressure Response to Zofenopril or Irbesartan Each Combined with Hydrochlorothiazide in High-Risk Hypertensives Uncontrolled by Monotherapy: A Randomized, Double-Blind, Controlled, Parallel Group, Noninferiority Trial. International Journal of Hypertension, 2015(), 97-108. https://doi.org/10.1155/2015/139465