Anti-Apoptosis Effects on Hearts of SHSST Cyclodextrin Complex in a Carbon Tetrachloride-Induced Cirrhotic Cardiomyopathy Rat Model

Cheng-Hsun Yang ； Wei-Jen Ting ； Pei-Ying Pai ； Sheng-Huang Chang ； Tsung-Jung Ho ； Jing-Ying Lin ； Fuu-Jen Tsai ； Viswanadha Vijaya Padama ； Yuhsin Tsai ； Chih-Yang Huang

《The Chinese Journal of Physiology》 58卷1期 (2015/02) Pp. 38-45

https://doi.org/10.4077/CJP.2015.BAD286

並列摘要

Cirrhotic cardiomyopathy (CCM) is a common cardiac dysfunction in patients waiting for orthotopic liver transplantation (OLT). Carbon tetrachloride (CCl_4) intraperitoneal (IP) injection has been reported as successful in a cirrhosis-induced CCM model. In this work, we used the same assay for CCM induction using CCl_4 (0.2mg/kg) IP injection twice per day for 14 days during the cardiac protection drugs treatment process. The cardiac protection drugs were silymarin (100mg/kg/day), baicalein (30mg/kg/day), San Huang Shel Shin Tang (SHSST, 30mg/kg/day) and β-cyclodextrin modified SHSST (SHSSTc, 30mg/kg/day and 300mg/kg/day). After 4 weeks of treatment, the SHSSTc cardiac protection effects were determined through activation of the IGF1R cell survival pathway and inhibition of Fas-FADD death domain induced-apoptosis. SHSSTc cardiac protection was enhanced through β-cyclodextrin modification, which increased bio-availability, and displayed stronger protective effects than silymarin and baicalein, both of which are well-known liver protection drugs. Thus, SHSSTc might provide the best therapeutic benefit in CCM treatment.

並列關鍵字

baicalein ； beta-cyclodextrin modified SHSST ； cirrhotic cardiomyopathy ； silymarin

參考文獻

Attama, A.A.,Nzekwe, I.T.,Nnamani, P.O.,Adikwu, M.U.,Onugu, C.O.(2003).The use of solid self-emulsifying systems in the delivery of diclofenac.Int. J. Pharm.262,23-28.

Baik, S.K.,Fouad, T.R.,Lee, S.S.(2007).Cirrhotic cardiomyopathy.Orphanet. J. Rare Dis.2,15.

Chien, C.F.,Wu, Y.T.,Tsai, T.H.(2011).Biological analysis of herbal medicines used for the treatment of liver diseases.Biomed. Chromatogr.25,21-38.

El-Shitany, N.A.,El-Haggar, S.,El-desoky, K.(2008).Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats.Food Chem. Toxicol.46,2422-2428.

Enache, I.,Oswald-Mammosser, M.,Woehl-Jaegle, M.L.,Habersetzer, F.,Di Marco, P.,Charloux, A.,Doutreleau, S.(2013).Cirrhotic cardiomyopathy and hepatopulmonary syndrome: prevalence and prognosis in a series of patients.Respir. Med.107,1030-1036.