- 期刊
Changes in rat Liver Microsomal Cytochrome P-450 and Enzymatic Activities after the Inhalation of n-hexane, Xylene, Methyl Ethyl Ketone and Methylchloroform for Four Weeks
並列摘要
Groups of Sprague-Dawley rats were exposed, by inhalation, to n-hexane (900 ppm, 3,240 mg/m^3), xylene (600 ppm, 2,625 mg/m^3), methyl ethyl ketone (800 ppm, 2,345 mg/m^3) and methylchloroform (800 ppm, 4,345 mg/m^3) for four weeks. Increased liver weights and liver to body weight ratios were observed for all the, solvents except n-hexane. An increased in vitro formation of certain metabolites of all the investigated substrates was found only in the rats exposed to xylene. The in vitro microsomal metabolism of biphenyl, benzo (a) pyrene, 4-androstene-3, 17-dione and 5α-androstane-3α, 17β-diol in combination with sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that n-hexane was without effect on rat liver microsomal cytochrome P-450 and that methyl ethyl ketone and methylchloroform depressed the formation of two metabolites of androstenedione but did not alter the concentration of cytochrome P-450 under the experimental conditions used. Xylene was shown to be a phenobarbital-like inducer of rat liver microsomal cytochrome P-450.
延伸閱讀
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