- 期刊
Formaldehyde Exposure and Respiratory and Related Cancers a case-referent Study among Finnish Woodworkers
並列摘要
A case-referent study was undertaken to investigate the associations between formaldehyde exposure and respiratory and related cancers. Fifty-seven such cancers from a retrospective cohort of male woodworkers formed the case group. They were matched by year of birth with 171 referents. Exposure to formaldehyde was assessed with job-exposure matrices. The median of the time-weighted average concentration was about 1 ppm, and the mean duration of exposure was 10 years among the exposed. Odds ratios (OR) were calculated for formaldehyde exposure (1.44), peak exposure to formaldehyde (1.26), and exposure to formaldehyde-containing wood dust (1.22). None of the values exceeded unity with statistical significance. Allowance was also made for a 10-year period from the onset of exposure. Birth year, cigarette smoking and exposure to wood dust, chlorophenols, pesticides, and terpenes were controlled by stratification. The adjusted ORs did not change appreciably. The highest OR was 1.95 for formaldehyde exposure without allowance for minimum latency, adjusted for exposure to terpenes. No exposure-response relation was observed for the level, duration, or dose (ppm-years) of formaldehyde exposure. The result is nonpositive and may be explained by absence of effect, by too short a follow-up, or by insufficient power for detecting a mild excess risk.
延伸閱讀
- Blair, A., Saracci, R., Stewart, P. A., Hayes, R. B., & Shy, C. (1990). Epidemiologic Evidence on the Relationship between Formaldehyde Exposure and Cancer. Scandinavian Journal of Work, Environment & Health, 16(6), 381-393. https://www.airitilibrary.com/Article/Detail?DocID=03553140-199011-201011220074-201011220074-381-393
- Hernberg, S., Collan, Y., Degerth, R., Englund, A., Engzell, U., Kuosma, E., Mutanen, P., Nordlinder, H., Hansen, H. S., Larsen, K. S., Søgaard, H., & Westerholm, P. (1983). Nasal Cancer and Occupational Exposures Preliminary Report of a Joint Nordic case-referent Study. Scandinavian Journal of Work, Environment & Health, 9(2), 208-213. https://www.airitilibrary.com/Article/Detail?DocID=03553140-198303-201011160100-201011160100-208-213
- Esping, B., & Axelson, O. (1980). A Pilot Study on Respiratory and Digestive Tract Cancer among Woodworkers. Scandinavian Journal of Work, Environment & Health, 6(3), 201-205. https://www.airitilibrary.com/Article/Detail?DocID=03553140-198008-201011150063-201011150063-201-205
- Jäppinen, P., Hakulinen, T., Pukkala, E., Tala, S., & Kurppa, K. (1987). Cancer Incidence of Workers in the Finnish Pulp and Paper Industry. Scandinavian Journal of Work, Environment & Health, 13(3), 197-202. https://www.airitilibrary.com/Article/Detail?DocID=03553140-198705-201011180019-201011180019-197-202
- Holmström, M., & Wilhelmsson, B. (1988). Respiratory Symptoms and Pathophysiological Effects of Occupational Exposure to Formaldehyde and Wood Dust. Scandinavian Journal of Work, Environment & Health, 14(5), 306-311. https://doi.org/10.5271/sjweh.1915