Thyroid Function as Assessed by Routine Laboratory Tests of Workers with long-term Lead Exposure

Matti Tuppurainen ； Gustav Wägar ； Kari Kurppa ； William Sakari ； Alexander Wambugu ； Bertil Fröseth ； Juha Alho ； Erkki Nykyri

《Scandinavian Journal of Work, Environment & Health》 14卷3期 (1988/05) Pp. 175-180

並列摘要

Thyroid function was studied in 176 male workers occupationally expose d to lead. The mean blood lead concentration of the workers was 2.70 (SD 1.15, range 0.70-6.45) μmol/l. The mean duration of lead exposure was 7.6 (range 0.1-20) years. The total thyroxine (T4), free thyroxine (FT4), total triiodothyronine (T3), and thyrotropin concentrations in serum were similar in the workers in the low and high blood lead categories. In regression equations the duration of lead exposure had a weak but significant negative association with T4 and FT4, and this association was particularly pronounced when the analyses were restricted to workers with the most intense lead exposure over time. Thus, the results suggest that thyroid function might be depressed as a result of intense long-term lead exposure.

並列關鍵字

duration of exposure ； hypothyroidism ； occupational