Urinary Styrene in the Biological Monitoring of Styrene Exposure

Fabriziomaria Gobba MD ； Claudia Galassi MD ； Sergio Ghittori BS\d ； Marcello Imbriani MD ； Franco Pugliese MD ； Alessandro Cavalieri MD

《Scandinavian Journal of Work, Environment & Health》 19卷3期 (1993/05) Pp. vi+175-182

https://doi.org/10.5271/sjweh.1484

並列摘要

GOBBAF, GALASSIC, GHITIORI S, IMBRIANIM, PUGLIESEF, CAVALLERIA. Urinary styrene in the biological monitoring of styrene exposure. Scand J Work Environ Health 1993;19:17582. The urinaryexcretion of styrene representsa promisingindicator of exposure to this solvent. Nevertheless extensive research under field conditions is scant. In this investigation 214 styrene-exposed workers from 10 fiberglass-reinforced plastics factories were studied. Environmental monitoring was performed by personal passive sampling. Blood styrene and the urinary excretion of styrene and its main metabolites, mandelic acid (MA) and phenylglyoxylicacid (PGA), were measured. The correlation coefficient between the time-weighted average of environmental styrene and the mean urinary excretion of styrene was 0.88 (0.91 after logarithmic transformation), compared with the 0.82 and 0.78 of the end-of-shift MA and PGA values, respectively. A high correlation (0.86) was also found between styrene in the blood and urine. The results, obtained under field conditions with a large group of exposed workers, confirm the usefulness of the urinary excretion of styrene as an exposure index for the biological monitoring of styrene exposure.

並列關鍵字

biological equivalent exposure limit ； biological exposure index ； glass-reinforced plastics ； styrene metabolites