- 期刊
Some Implications of Genetic Biomarkers in Occupational Epidemiology and Practice
並列摘要
This paper addresses the use of genetic biomarkers in occupational epidemiology and some of the scientific, ethical, and social implications for epidemiologists and practitioners to consider, including issues involving individual risk estimation, the communication of epidemiologic results, and the translation of epidemiologic data into clinical or occupational health practice. Three scenarios from the occupational setting illustrate some of these issues and implications. The scenarios involve glutathione-S-transferase theta 1 (GSTT1) and hematopoietic cancer in hospital workers, human leukocyte antigen coding for glutamic acid in the 69th position (HLA DPB1(superscript E69)) and chronic beryllium disease in beryllium workers, and peripheral myelin protein 22 (PMP22) deletion and carpal tunnel syndrome in railroad track workers. Epidemiologic research involving genetic biomarkers requires the application of genetic tests and can be considered on a continuum between basic sciences and clinical and occupational and public health practice for which questions of test relevance, validity, and utility become important.
並列關鍵字
epidemiology ； ethics ； genetics ； genetic testing ； genomics ； molecular epidemiology ； polymorphisms延伸閱讀
- Vainio, H. (2004). Genetic Biomarkers and Occupational epidemiology-recollections, Reflections and Reconsiderations. Scandinavian Journal of Work, Environment & Health, 30(1), 1-3. https://www.airitilibrary.com/Article/Detail?DocID=03553140-200401-201011100045-201011100045-1-3
- So, H. C. (2010). Genetic architecture and risk prediction of complex diseases [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200018920
- Fu, P. P., Wu, Y. S., Lai, J. S., Chung, M. I., & Lai, C. C. (1993). Biomarkers: An Important Strategy for Human Health Risk Assessment. 藥物食品分析, 1(1), 7-14. https://www.airitilibrary.com/Article/Detail?DocID=10219498-199301-1-1-7-14-a
- Mastin, J. P., Henningsen, G. M., & Fine, L. J. (1992). Use of Biomarkers of Occupational Musculoskeletal Disorders in Epidemiology and Laboratory Animal Model Development. Scandinavian Journal of Work, Environment & Health, 18(suppl 2), 85-87. https://www.airitilibrary.com/Article/Detail?DocID=03553140-199212-201011180076-201011180076-85-87
- Burdorf, A. (1992). Exposure Assessment of Risk Factors for Disorders of the Back in Occupational Epidemiology. Scandinavian Journal of Work, Environment & Health, 18(1), 1-9. https://www.airitilibrary.com/Article/Detail?DocID=03553140-199201-201011180069-201011180069-1-9