Surface Analysis and Dynamic Mechanical Studies of Polyurethane-Polylactide Blends

本研究將聚L-乳酸或乳酸-甘醇酸之共聚物與醫用級聚胺基甲酸酯(PU)兩者之間利用共溶劑法進行混摻。在以混鹽浸濤法成型後，以X光電子光譜（ESCA）分析其表面元素，並以動態機械測量（DMA）來檢視其中PU微相分離的程度。在先前的研究已發現，在PU中只要加入少量聚乳酸系列的高分子（5～20％）進行混摻，即可有效地提高在體外內皮細胞於其表面上的生長速率，同時也能在體內促進新血管內膜的形成。而本研究則進一步顯示，前述之促進作用乃是來自混摻之後：（1）表面具有較多C-O官能基：（2）整體有較快的降解速率；尤其是（3）摻合物使原有PU內微相分離的程度增加。此種混摻的效果也暗示了生物降解性高分子在提高PU應用於組織工程方面所具有的潛力。

關鍵字

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並列摘要

Poly(L-lactide) or poly(lactide-co-glycolide) was blended with a commercial medical-grade polyurethane using a mutual solvent technique. After preparation by salt casting, the surface was characterized by the electron spectroscopy for chemical analysis (ESCA); and the microphase separation was studied by a dynamic mechanical analyzer (DMA). It was formerly reported that blending with these biodegradable polymers significantly enhanced the endothelial attachment and growth in vitro and neo-intima formation in vivo. In the current study, it was shown that this enhancement could be attributed to: O) the higher C-O/Ctotal percentage on the surface of the blends as detected by ESCA; (2) the larger bulk degradation rate of the blends; and especially (3) the microphase separation in the blends demonstrated by DMA. The results suggested blending as an alternative to chemical modification and implied potential Blending formulae from other biodegradable polymers for the purpose of improving the cellular affinity and tissue repair on polyurethanes.

並列關鍵字

Polyurethane ； Polylactide ； Blends ； Degradation ； ESCA ； Microphase Separation

國際替代計量

Surface Analysis and Dynamic Mechanical Studies of Polyurethane-Polylactide Blends

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