The research is to establish a two-dimensional hydrogeological model to assess the inflow of the eastern part of transbasin diversion tunnel of Tsengwen Reservoir. The computer program, MODFLOW, is applied to estimate the variance of inflow during the excavation period and evaluate the instant inflow and the accumulated inflow against the ground-water level. The results show that when the tunnel passes through vicinity of Laonung fault and the hinge of Laorenxi anticline, the greatest instant inflow is occurred and the value is about from 0.0505/l/s.m to 4.71 l/s.m; When through Kaochung fault with the higher water table and high-permeability, the value of the greatest instant inflow is about 4.71 l/s.m.