Doppler Studies Can Predict Long-Term Outcome of Growth-Restricted Fetuses

Susumu Miyashita ； Yoshihide Chiba

《Journal of Medical Ultrasound》 10卷2期 (2002/06) Pp. 86-93

並列摘要

Objectives: To evaluate measures related to adverse long-term outcomes of growth-restricted fetuses, and to compare their clinical efficacies.
Methods: One hundred and nineteen growth-restricted fetuses were examined prospectively. All fetuses were singletons and free from any morphologic anomaly or abnormal karyotype. Standardized estimated fetal body weight (EFBWdSD), nonstress test, contraction stress test, standardized resistance index of the umbilical artery (UmA) and middle cerebral artery, pH of fetal blood (sampled by cordocentesis) and oligohydramnios were all analyzed. All fetuses were delivered within 10 days after fetal blood sampling and were monitored for at least 3 years after birth. All findings were recorded cross-sectionally and analyzed by logistic regression modeling.
Results: Sixteen fetuses showed adverse outcomes including neonatal death, infantile death, cerebral palsy and/or developmental retardation. UmA-standardized resistance index (RIdSD) ≥+4.0 and fetal blood pH＜7.32 were independent variables for adverse outcomes. The adjusted odds ratios (95% confidence interval) for these factors were 16.8 (3.23-87.0) and 7.76 (1.55-39.0), respectively.
Conclusions: UmA-RIdSD and fetal blood pH are readily available independent predictors of adverse long-term outcome of intrauterine growth-restricted fetuses.

並列關鍵字

Doppler imaging ； fetal growth restriction ； outcome ； ultrasound