Correlation of CD44v5 Expression with Invasiveness and Prognosis in Renal Cell Carcinoma

腎細胞癌之CD44v5表現與其侵襲性及預後之相關

吳勝堂(Sheng-Tang Wu) ； 于大雄(Dah-Shyong Yu) ； 孫光煥(Guang-Huan Sun) ； 謝達士(Dar-Shih Hsieh) ； 陳安(An Chen) ； 陳宏一(Hong-I Chen) ； 張聖原(Sun-Yran Chang)

《Journal of the Formosan Medical Association》 102卷4期 (2003/04) Pp. 229-233

https://doi.org/10.29828/JFMA.200304.0004

並列摘要

Background and Purpose: The expression of specific CD44isoforms is associated with metastasis and poor prognosis in human malignant tumors. We retrospectively investigated the expression of the CD44 variant isoform v5 (CD44v5) in human renal cell carcinoma (RCC) specimens by immunohistochemistry.
Methods: We studied the expression of CD44v5 immunohistochemistry in archival tissue specimens from 72 RCC patients (47 men and 25 women) with a mean age of 6031 years (range, 30to 83 years) who underwent resection in our hospital from 1986 to 1996. The patients were divided into non-invasive (pT1, pT2, and pT3a; n=49) and invasive groups (pT3b, pT3c, and any T with N +; n=23). Among the 72 patients, 67were followed for at least 60months (up to 190 months) after radical nephrectomy. Twenty nine renal specimens, including 15 of normal renal parenchyma and 14 of inflammatory of immune renal diseases, were used as controls.
Results: All control group tissues expressed CD44v5. CD44v5 expression was detected in 66 of 72 RCC specimens (91.7%). In general, the expression of CD44v5 was higher in the non-invasive group [47/49 (95.5%) vs 19/23 (82.6%), p＜0.05]. Five cases were lost to follow-up. Thirty three of 67 patients (49.3%) died of RCC-related causes during the follow-up period. The CD44v5 non-expression group had a higher mortality rate than the expression group [4/5 (80%) vs 29/62 (46.8%), p＜0.001]. The 5-year and 10-year survival rates were significantly higher in patients with CD44v5 expression than in those without (p＜0.001).
Conclusions: This study found that CD44v5 expression was greater in early stage than in advanced stage RCC and was associated with tumor progression and long-term survival. Although the survival analysis showed both tumor stage and CD44v5 expression were significant prognostic factors in RCC, only tumor stage remained an independent factor.

並列關鍵字

Antigens ； CD44 ； carcinoma ； renal cell ； Immunohistochemistry ； Prognosis ； Tumor markers ； biological