Metabolic Syndrome and its Contribution to Coronary Artery Disease in Non-Diabetic Subjects

代謝症候群在非糖尿病者之冠心症所扮演的重要性

林榮宗(Rong-Tsung Lin) ； 李文珍(Wen-Jane Lee) ； 鄭啟源(Chii-Yeng Jeng) ； 許惠恆(Wayne Huey-Herng Sheu) ； 陳穎從(Ying-Tsung Chen)

《Journal of the Formosan Medical Association》 103卷4期 (2004/04) Pp. 317-320

https://doi.org/10.29828/JFMA.200404.0013

並列摘要

Background and Purpose: People with the metabolic syndrome are at increased risk for developing diabetes mellitus and coronary artery disease (CAD). This study assessed the 5 risk factors of metabolic syndrome in non-diabetic individuals with angiographically-documented CAD.
Methods: To estimate the CAD risk associated with metabolic syndrome, we examined the 5 components of metabolic syndrome, defined by the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP)III, including blood pressure (≥ 130/85 mm Hg), fasting glucose (≥ 110 mg/dL), fasting triglycerides (≥ 150 mg/dL), high-density lipoprotein (HDL) cholesterol level (men ＜ 40 mg/dL; women＜50 mg/dL), and abdominal obesity (waist circumference defined by the Department of Health, Taiwan: men ＞ 90cm; women ＞ 80 cm) among 139 non-diabetic patients with angiographically-documented CAD and 139 age-and gender-matched non-diabetic control subjects.
Results: Metabolic syndrome was found to be more prevalent in subjects with CAD than subjects without CAD (51.8% vs 18.7%; p＜0.001). Multiple logistic regression analysis showed that hypertension was the strongest predictor of CAD, followed by higher fasting glucose and lowered HDL cholesterol. These 5 factors accounted for 41.3% of total risk for CAD without diabetes.
Conclusions: Our data revealed that the prevalence of metabolic syndrome was higher in this group of patients with angiographically-diagnosed CAD without diabetes than in controls.

並列關鍵字

Case-control studies ； Coronary artery disease ； Metabolic syndrome X ； Prevalence ； Risk factors