- 期刊
Negative Expiratory Pressure in the Assessment of Bronchodilator Response: Comparison of Spirometry and the Interrupter Method
並列摘要
Background and Purpose: The negative expiratory pressure (NEP) method offers a simple and rapid assessment of expiratory flow limitation (EFL) during tidal respiration. This study compared the value of NEP in the assessment of the bronchodilator test (BDT) with those of spirometry and the interrupter method. Methods: Thirty two patients referred to the lung function laboratory for BDT were investigated. All patients underwent spirometry, interrupter airway resistance (Rint) and NEP measurements in the sitting position before and after inhalation of 500μg of terbutaline. A positive BDT was defined as an increase in the forced expiratory volume in 1 second (FEV1) of ≥12%. Results: The ratio of FEV, to forced vital capacity (FVC) was less than 70% in 21(65.6%) patients, but EEL as, demonstrated b) NEP (EFL-N) was present in only 10 patients (31.3%). The baseline EFL-N was only weakly correlated with FEV1(r=-0.36, p=0.04), but not with Rint or FEV1/FVC. Among the 14 patients with positive BDT results, the change in FEV, was correlated with the change in Rint (r=-0.69, p＜0.01), but not with the change in EFL-N. Conclusions: These data suggest that, compared with spirometry and the interrupter method, NEP applied in the sitting position is not sensitive in the assessment of bronchodilator response in patients with obstructive airway disorders.
延伸閱讀
- 曲長科、陳昌文（2009）。Positive End-expiratory Pressure and Tidal Volume in the Acute Respiratory Distress Syndrome-A Continuous Controversy。內科學誌，20(3)，197-202。https://doi.org/10.6314/JIMT.2009.20(3).01
- Lin, M. H., Su, J. C., Cheng, C. H., Lin, H. C., Wang, C. H., Chiang, L. L., & Kuo, H. P. (2003). Different Mechanisms of Airway Hyperresponsiveness between Exercise and Methacholine-Induced Bronchoconstriction in Chronic Asthma. 胸腔醫學, 18(2), 116-123. https://www.airitilibrary.com/Article/Detail?DocID=10239855-200304-18-2-116-123-a
- Chao:蔡富項, C. L., & Lee, S. W. (1999). Inflammatory, Immunological and Clinical Comparisons of Short-and Long-acting Bronchodilators in Mild and Moderate Bronchial Asthma Patients. 中華民國急救加護醫學會雜誌, 10(2), 61-71. https://doi.org/10.30018/JECCM.199906.0003
- Su, C. L., Chiang, L. L., Chiang, T. Y., Yu, C. T., Kuo, H. P., & Lin, H. C. (2007). Domiciliary Positive Expiratory Pressure Improves Pulmonary Function and Exercise Capacity in Patients with Chronic Obstructive Pulmonary Disease. Journal of the Formosan Medical Association, 106(3), 204-211. https://doi.org/10.29828/JFMA.200703.0016
- Alaparthi, G. K., Augustine, A. J., Anand, R., & Mahale, A. (2016). Comparison of Diaphragmatic Breathing Exercise, Volume and Flow Incentive Spirometry, on Diaphragm Excursion and Pulmonary Function in Patients Undergoing Laparoscopic Surgery: A Randomized Controlled Trial. Minimally Invasive Surgery, 2016(), 23-34. https://doi.org/10.1155/2016/1967532