- 期刊
Deletions of Chromosome 1p and 15q are Associated with Aggressiveness of Gastrointestinal Stromal Tumors
並列摘要
Background/Purpose: Site-dependent profiles of chromosome imbalances (CIs) have been reported in gastrointestinal stromal tumors (GISTs). However, the role of specific CIs in association with metastasis is not clear. Methods: Thirteen resected liver metastatic GISTs, including seven from the stomach and six from the small intestine, were analyzed using comparative genomic hybridization (CGH). The CIs associated with metastatic risk were assessed by comparing them with those identified in our previous study of 25 primary GISTs, including 14 from the stomach and 11 from the small intestine. Results: Synchronous detection of liver metastasis was found more often in patients with intestinal than gastric GIST (5/6 vs. 2/7, p = 0.048). When compared with the primary tumors, the CI profile of liver metastases was similar in the intestinal group, but became more complex in the gastric group. Deletions of chromosomes 1p and 15q were very common (＞ 80%) in primary and metastatic tumors of the intestinal group, and exhibited a trend towards increase in the metastatic tumors of the gastric group. Both groups had a doubling in the frequency of 22q deletion in the liver metastases, which was not significantly different. Other CIs, including 9p deletion, increased significantly in the liver metastases of the gastric group, but not in the intestinal group. Conclusion: Our results, together with clinical findings, indicated a CGH profile associated with the intrinsic aggressiveness of the GISTs. Deletion of 1p and 15q play a critical role in the acquisition of aggressiveness during early GIST development.
延伸閱讀
- Sander, M. A. G. (2014). Investigation of the c-KIT-ETV1 Axis in Tumorigenesis and Progression of Gastrointestinal Stromal Tumors [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2014.01483
- Koumarianou, A., Economopoulou, P., Katsaounis, P., Laschos, K., Dadioti, P. A., Martikos, G., Rogdakis, A., Tzanakis, N., & Boukovinas, I. (2015). Gastrointestinal Stromal Tumors (GIST): A Prospective Analysis and an Update on Biomarkers and Current Treatment Concepts. Biomarkers in Cancer, 2015(S1), 1-7. https://doi.org/10.4137/BIC.S25045
- Guo, T. (2009). Identification of tumor suppressor genes in the commonly deleted region of chromosome 6q in NK-cell malignancies [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200019668
- Chou, C. C., Chou, M. J., & Tzen, C. Y. (2010). Prediction of KIT Mutation in Gastrointestinal Stromal Tumors by the Immunoprofile of the Tumor Cells. Journal of the Formosan Medical Association, 109(1), 25-31. https://www.airitilibrary.com/Article/Detail?DocID=09296646-201001-201003030060-201003030060-25-31
- Chiu, Y. C., Lin, J. W., Changchien, C. S., Huang, C. C., Liu, S. Y., Yi, L. N., Chiu, K. W., Wu, K. L., Chen, Y. Y., Chou, F. F., & Hu, T. H. (2005). Clinicopathological Characteristics and Prognosis of Patients with Small Intestinal Stromal Tumors. Journal of the Formosan Medical Association, 104(12), 905-912. https://doi.org/10.29828/JFMA.200512.0004