Effects of Phytosterols in Diacylglycerol as part of diet Therapy on Hyperlipidemia in Children

以雙醯甘油中的植物固醇作為飲食治療的一部份對高脂血症兒童的影響

Takeshi Matsuyama ； Kentaro Shoji ； Hideto Takase ； Isamu Kamimaki ； Yuriko Tanaka ； Atsuko Otsuka ； Hiroyuki Watanabe ； Tadashi Hase ； Ichiro Tokimitsu

《Asia Pacific Journal of Clinical Nutrition》 16卷1期 (2007/03) Pp. 40-48

https://doi.org/10.6133/apjcn.2007.16.1.06

摘要

背景：日本兒童高脂血症的發生率逐漸上升，但是藥物治療對於這些兒童是有限的。成年人攝取含有4%植物固醇的雙醯甘油（PS/DAG）可降低血清總膽固醇及低密度脂蛋白膽固醇（LDL-C）濃度。在本研究，我們評估以PS/DAG當做飲食治療的一部份，其對患有高血脂症的小兒科病人的影響。方法：小兒科病人其血清膽固醇≥ 5.18mmol/L （200 mg/dL）或是三酸甘油酯≥1.70mmol/L （150mg/dL）的高脂血症患者，連續攝取含有PS/DAG（每天總攝取量10公克）的麵包六個月。評估受試者在開始攝取之前及攝取後的2、4、6個月和攝取週期之後的4個月之血液生化值。結果：熱量攝取或膽固醇攝取在研究週期間都沒有顯著差異。攝取PS/DAG 4個月後，LDL-C、lipoprotein(a) [Lp(a)]、游離脂肪酸及總酮體量顯著降低。七名家族性高膽固醇血症病人，除了LDL-C 及Lp(a)外，總膽固醇及脂蛋白粒子剩餘體－膽固醇也顯著降低。結論：PS/DAG可改善藥物治療受到限制的高脂血症小兒科病人的血清脂質代謝，本研究建議PS/DAG可能可以降低各種受到高脂血症誘導而發展的各種疾病危險性。

關鍵字

雙醯甘油 ； 植物固醇 ； 膽固醇 ； 脂蛋白（a） ； 兒童

並列摘要

Background: The incidence of hyperlipidemia in children is increasing in Japan, but drug therapy for such children is limited. The ingestion of 4% phytosterols-containing diacylglycerol (PS/DAG) decreases serum total cholesterol and low density lipoprotein cholesterol (LDL-C) concentrations in adults. In the present study, we examined the effect of PS/DAG as part of a diet therapy in pediatric patients with hyperlipidemia. Methods: Pediatric patients with hyperlipidemia with ≥ 5.18mmol/L (200 mg/dL) serum total cholesterol and/or ≥1.70mmol/L (150 mg/dL) triglycerides (N = 22) ingested bread containing PS/DAG (total daily intake, 10g) for 6 months. Blood chemistry was examined prior to and 2, 4, 6 months after the initiation of ingestion, and 4 months after the ingestion period. Results: No significant differences in energy intake or cholesterol intake during the study period were found. After 4 months of ingestion of PS/DAG, LDL-C, lipoprotein(a) [Lp(a)], free fatty acids and total ketone bodies decreased significantly. In seven patients with familial hypercholesterolemia, total cholesterol and remnant-like lipoprotein particles (RLP)–cholesterol also significantly decreased in addition to LDL-C and Lp(a). Conclusions: PS/DAG improves serum lipid metabolism in pediatric patients with hyperlipidemia for whom drug therapy is limited, suggesting that PS/DAG may reduce the risk of developing various diseases induced by hyperlipidemia.

並列關鍵字

diacylglycerol ； phytosterols ； cholesterol ； lipoprotein(a) ； children