- 期刊
The Mechanism of 3-Methoxy Puerarin on Decreasing the Cerebral Ischemia-Reperfusion Injury in Rats
並列摘要
The aim of this study was to explore the mechanism of 3-methoxy puerarin on decreasing the cerebral ischemiareperfusion injury in rats. Before the model of cerebral ischemia-reperfusion injury was made, the rats in one group (3-methoxy puerarin group, 3-MP group) were pretreated with 3-methoxy puerarin (100mg/kg) by gavageing two times per day for seven days. At an hour before operation, the rats in the 3-MP group were additionally given 3-methoxy puerarin by gavageing once. The level of prostacyclin (PGI2) and the expression of endothelin-1 (ET-1) mRNA in cerebral tissue, the activity of plasma tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) were measured. Cerebral tissue pathologic changes were also observed. The levels of PGI2 in cerebral tissue and the activity of plasma t-PA in 3-MP group were significantly higher than those in the group of cerebral ischemia-reperfusion injury (CIRI group) (p＜0.01). The activity of plasma PAI and the expression of ET-1 mRNA in cerebral tissue in 3-MP group were significantly lower than those in CIRI group (p＜0.01). The cerebral tissue pathologic changes were significant in CIRI group, which were significantly ameliorated in the 3-MP group. The study showed, in the rat model of cerebral ischemia-reperfusion injury, 3-methoxy puerarin can not only increase the level of PGI2 in cerebral tissue and the activity of plasma t-PA, but also inhibit the activity of plasma PAI and the expression of ET-1 mRNA in cerebral tissue. Those findings might be the mechanisms behind the protecting effects of 3-methoxy puerarin on the cerebral ischemia-reperfusion injury.
延伸閱讀
- Azouz, A. A., Omar, H. A., yousef, A. M. A., Sherbiny, G. A. E., & Latif, H. A. A. (2015). Different Protective Effects of Trimetazidine against Renal Ischemia/Reperfusion Injury in Rats. British Journal of Pharmacology and Toxicology, 6(3), 64-69. https://www.airitilibrary.com/Article/Detail?DocID=20442467-201507-201509150007-201509150007-64-69
- Yang, C. C., Cheng, D. L., Leiao, K., Fan, J. S., Chen, C. F., & 葉裕祥 (2005). Prior Induction of Heme Oxgenase-1 with Cordycepin Attenuates Renal Ischemia and Reperfusion Injury in Rats. 北市醫學雜誌, 2(7), 618-624. https://doi.org/10.6200/TCMJ.2005.2.7.04
- 鄭敬學（2012）。The Protective Effects of Ischemic Postconditioning on Intestinal Ischemia-Reperfusion Injury among Rats〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2012.00430
- 杜元博（2013）。The protective mechanism of far-infrared irradiation(FIR) against ischemia-reperfusion injury on the testes in rats〔博士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2013.03075
- Cai, F., Li, C. R., Wu, J. L., Chen, J. G., Liu, C., Min, Q., Yu, W., Ouyang, C. H., & Chen, J. H. (2006). Theaflavin Ameliorates Cerebral Ischemia-Reperfusion Injury in Rats Through Its Anti-Inflammatory Effect and Modulation of STAT-1. Mediators of Inflammation, 2006(), 142-150. https://doi.org/10.1155/MI/2006/30490