Hyperuricemia and Metabolic Syndrome in Taiwanese Children

臺灣兒童之高尿酸血症與代謝症候群

Meei-Shyuan Lee ； Mark L. Wahlqvist ； Hsiao-Li Yu ； Wen-Harn Pan

《Asia Pacific Journal of Clinical Nutrition》 16卷S2期 (2007/07) Pp. 594-600

https://doi.org/10.6133/apjcn.2007.16.s2.11

摘要

兒童代謝適能在過渡及高度經濟發展地區漸受關切，而代謝症候群（MS）在這個年齡層也愈常見。當MS出現，高尿酸血症也同時出現。臺灣的研究指出原住民及華人其高尿酸血症盛行率均極高。採用臺灣學童營養及健康調查（男：1227 人；女：1057人）的資料，評估尿酸（UA）及MS在兒童的關係。平均血清UA隨年齡上升，男童範圍為5.69mg/dL到7.11mg/dL，女童為5.61mg/dL到6.13md/dL。男童UA濃度(6.07 mg/dL vs. 5.74mg/dL)及高尿酸血症(UA ≥ 7mg/dL)(26.5% vs. 18.8%)均較女童高。用ATP III標準，5.56％的男童及6.39％的女童有代謝症候群。血清尿酸與MS指標緊密相關，尤其腰圍（r=0.387）。腰圍本身可解釋18％血清尿酸的變異。血清尿酸及高尿酸血症均是代謝症候群的危險因數（UA每1 mg/dL, OR: 1.54, 95% CI: 1.36-1.74; hyperuricemia, OR: 3.73, 95% CI: 2.47-5.62），控制年齡及區域後，關係更明顯。公共衛生及臨床工作者對代謝症候群這個變化中的健康問題，應多重視腹部肥胖或尿酸。

關鍵字

血清尿酸 ； 高尿酸血症 ； 代謝症候群 ； 腹部肥胖 ； 國小學童 ； 臺灣 ； 臺灣學童營養及健康調查

並列摘要

Metabolic fitness in childhood is of increasing concern in transitional and advanced economies as the metabolic syndrome (MS) is recognized more often in this age group. As the MS appears, so also does hyperuricemia. Studies in Taiwan have identified both indigenous and Chinese with high prevalence of hyperuricemia. Data (1227 boys and 1057 girls, aged 6-12) from the Nutrition and Health Survey in Taiwan Elementary School Children (NAHSIT Children 2001-2002) were used to appraise the association between uric acid (UA) and MS in children. Mean serum urate increases by age, ranging from 5.69 mg/dL to 7.11 mg/dL for boys and 5.61 mg/dL to 6.13md/dL for girls. Boys have higher UA concentrations (6.07 mg/dL vs. 5.74 mg/dL) and hyperuricemia (UA ≥ 7mg/dL) rate (26.5% vs. 18.8%) than girls. Children of Mountain areas have higher rates of hyperuricemia (boys:39.2%, girls: 30.1%). 5.56% of boys and 6.39% of girls were classified as having the MS by ATP III criteria. Serum urate was closely correlated with the MS parameters, and waist circumference (WC) in particular (r=0.387). WC alone accounted for 18% of variance of serum urate concentration. Both serum urate and hyperuricemia are significant risk factors for the MS (serum urate in mg/dL, OR: 1.54, 95% CI: 1.36-1.74; hyperuricemia, OR: 3.73, 95% CI: 2.47-5.62). Adjustment for age and region accentuate these relationships. Not only abdominal fatness, but also uric acid status, or both together may be of interest to public health workers and clinicians in regard to the transitional health problem of MS.

並列關鍵字

serum urate ； hyperuricemia ； metabolic syndrome ； abdominal obesity ； elementary school children ； Taiwan ； Nutrition and Health Survey in Taiwan Elementary School Children (NAHSIT Children 2001-2002)