- 期刊
Intake of Vitamin A-Rich Foods and Lung Cancer Risk in Taiwan: With Special Reference to Garland Chrysanthemum and Sweet Potato Leaf Consumption
臺灣地區富含維生素A食物的攝取與罹患肺癌的風險：尤指茼蒿及地瓜葉的食用研究
摘要
我們利用病例對照研究法，探討攝食臺灣盛產且富含維生素A的食物與罹患肺癌危險性之關係。共收案301位原發肺癌新病人、602位醫院對照病人和602位鄰居對照受試者，使用食物頻率問卷估量其13種食物和維他命補充劑之攝取量後，以條件式羅吉斯迴歸模式估算肺癌病人與每組對照組於共變數調整後勝算比（adjusted odds ratio: AOR）與其95%信賴區間（95% CI）。結果發現從13種食物中攝食維生素A、α胡蘿蔔素和β胡蘿蔔素愈高者，其罹患肺癌的危險性愈低。而攝食較多份數的蔬菜（病例組與對照組之高vs.低四分位之調整後勝算比為0.67－0.70，95% CI為0.42－1.08，趨勢p值為0.04）、茼蒿（高vs.低三分位調整後勝算比分別為0.58－0.74，95% CI為0.37－1.14，趨勢p值≤0.04）或地瓜葉（高vs.低三分位調整後勝算比分別為0.43－0.65，95% CI為0.28－0.96，趨勢p值≤0.03）者，其罹患肺癌的危險性則較低。結論：攝食較多富含維生素A的蔬菜，特別是茼蒿和地瓜葉，提供了對肺癌保護的可能性。
並列摘要
A case-control study was conducted to investigate the association between the consumption of local common foods that are rich in vitamin A and the risk of lung cancer in Taiwan. A total of 301 incident lung cancer cases, 602 hospital controls, and 602 neighborhood controls were recruited. The consumption of 13 food items and vitamin supplements was estimated by use of a food frequency questionnaire. The conditional logistic regression models were used to estimate the adjusted odds ratios (AOR) and 95% confidence intervals (CI) for lung cancer risk with each control group as reference by adjustment of covariates. A reduced risk for lung cancer was found to be associated with increased intakes of vitamin A, α-carotene, and β-carotene from 13 food items. More servings of vegetables (AOR for the highest versus the lowest quartile = 0.67-0.70, 95% CI = 0.42-1.08, plinear trend = 0.04), garland chrysanthemum (AOR for the highest versus the lowest tertile = 0.58-0.74, 95% CI = 0.37-1.14, plinear trend ≤ 0.04) and sweet potato leaves (AOR for the highest versus the lowest tertile = 0.43-0.65, 95% CI = 0.28-0.96, plinear trend ≤ 0.03) were associated with the reduced risk for lung cancer. In conclusion, higher consumption of vitamin A-rich vegetables, especially garland chrysanthemum and sweet potato leaves might provide potential protection from lung cancer.