Application of Refractometry to Quality Assurance Monitoring of Parenteral Nutrition Solutions

利用屈光計作為監測靜脈營養輸液品質控制工具

Wei-Kuo Chang ； You-Chen Chao ； Ming-Kung Yeh

《Asia Pacific Journal of Clinical Nutrition》 17卷1期 (2008/03) Pp. 116-122

https://doi.org/10.6133/apjcn.2008.17.1.18

摘要

Parenteral nutrition (PN) solution contains various concentrations of dextrose, amino acids, lipids, vitamins, electrolytes, and trace elements. Incorrect preparation of PN solution could lead to patient death. In this study we used the refractive index as a quality assurance tool to monitor the preparation of PN solution. Refractive indices of single nutrient components and PN solutions consisting of various concentrations of dextrose, amino acids, electrolytes, and lipids were measured. A mathematical equation and its linear plot were generated then used to predict the refractive index of the PN solution. The best-fit refractive index for PN solution (i.e., the predicted refractive index) = 0.9798 × (% dextrose) + 1.2889 × (% amino acids) + 1.1017 × (% lipids) + 0.9440 × (% sum of the electrolytes) + 0.5367 (r^2 = 0.99). This equation was validated by comparing the measured refractive indices of 500 clinical PN solutions to their predicted refractive indices. We found that 2 of the 500 prepared samples (0.4%) had less than the predicted refractive index (＜ 95%). Refractive index can be used as a reliable quality assurance tool for monitoring PN preparation. Such information can be obtained at the bedside and used to confirm the accuracy of the PN solution composition.

關鍵字

屈光計 ； 屈光值 ； 品質保證 ； 營養 ； 靜脈營養

並列摘要

Parenteral nutrition (PN) solution contains various concentrations of dextrose, amino acids, lipids, vitamins, electrolytes, and trace elements. Incorrect preparation of PN solution could lead to patient death. In this study we used the refractive index as a quality assurance tool to monitor the preparation of PN solution. Refractive indices of single nutrient components and PN solutions consisting of various concentrations of dextrose, amino acids, electrolytes, and lipids were measured. A mathematical equation and its linear plot were generated then used to predict the refractive index of the PN solution. The best-fit refractive index for PN solution (i.e., the predicted refractive index) = 0.9798 × (% dextrose) + 1.2889 × (% amino acids) + 1.1017 × (% lipids) + 0.9440 × (% sum of the electrolytes) + 0.5367 (r^2 = 0.99). This equation was validated by comparing the measured refractive indices of 500 clinical PN solutions to their predicted refractive indices. We found that 2 of the 500 prepared samples (0.4%) had less than the predicted refractive index (＜ 95%). Refractive index can be used as a reliable quality assurance tool for monitoring PN preparation. Such information can be obtained at the bedside and used to confirm the accuracy of the PN solution composition.

並列關鍵字

refractometer ； refractive index ； quality assurance ； nutrition ； parenteral nutrition