Effect of Iron Fortification of Nursery Complementary Food on Iron Status of Infants in the Dprkorea

本研究想了解在煮粥水中添加硫酸亞鐵，而讓嬰兒攝取米粥後，其體內鐵的狀況。自北韓36個育嬰所徵招年紀6-12個月大的嬰兒234位，隨機分配為鐵攝取組和安慰劑組。一開始，幾乎一半的嬰兒血紅素少於110g/L，而且兩組在基礎血紅素濃度和貧血盛行率上都沒有差異。鐵攝取組每天攝取含10毫克鐵的米粥，是將硫酸亞鐵加入水中，再用此水烹煮米粥，而安慰劑組則是攝取沒有強化過的粥。試驗期6個月後，測量血紅素、血清鐵蛋白和紅血球比容積。結果發現鐵攝取組比安慰劑組嬰兒貧血的比例較低，血紅素和血清鐵蛋白濃度較高，缺鐵性貧血率較低。硫酸亞鐵加入水中和米粥一起烹煮，能使北韓缺鐵性貧血嬰兒的盛行率降低且無有害副作用。這樣簡單的強化方法或許適用於北韓的全國性計劃和有大型育嬰所的其它國家。

關鍵字

鐵狀況；缺鐵性貧血；添加鐵；嬰兒；育嬰所食品

並列摘要

The aim of this study was to determine the iron status of infants who consumed porridge cooked in water with added ferrous sulphate. A total of 234 infants, aged 6~12 months, were recruited from 36 nurseries in the Democratic Peoples Republic of Korea (DPRK North Korea) and randomly divided into iron (Fe) and placebo groups. At baseline, almost half the children had Hb＜110 g/L and no significant differences between the two groups were found with regard to hemoglobin concentration and anemia prevalence. The Fe group received rice porridge fortified with 10 mg of iron (as ferrous sulfate) per day, added to the water in which the rice was cooked and the placebo group non-fortified cereal for 6 months. After which, the hemoglobin (Hb), serum ferritin (SF) and packed cell volume (PCV) were measured and it was found that the proportion of children with anemia (Hb＜110 g/L) was lower (24.3% v 48.1% p＜ 0.01), the Hb levels (117.6 g/L v 109.8 g/L p＜0.001) and serum ferritin were higher (40.7 v 26.8 mcg/L p＜0.001); and iron deficiency anemia (Hb＜110 g/L, SF＜12 mcg/L) was lower in the Fe group (3% v 22% p＜0.001) when compared to the placebo group. Ferrous sulphate, added to the water in which rice was cooked, lowered the prevalence of iron deficiency anemia of infants in the DPRK with no adverse reactions. This simple fortification would be suitable as a nationwide program in the DPRK and other countries with large infant nurseries.

並列關鍵字

iron status ； iron deficiency anemia (IDA) ； iron fortification ； infant ； nursery food

國際替代計量

Effect of Iron Fortification of Nursery Complementary Food on Iron Status of Infants in the Dprkorea

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