- 期刊
Body Mass Index (BMI) As a Major Factor in the Incidence of the Metabolic Syndrome and Its Constituents in Unaffected Taiwanese from 1998 To 2002
身體質量指數為1998-2002台灣人代謝症候群及其組成發生的一個主要因素
摘要
本研究以台灣一大型健檢中心會員定期健檢資料來探討代謝症候群與其組成發生的因素。研究對象為起始無代謝症候群之9,785位台灣美兆健檢中心會員，年齡介於19至84歲，於1998至2002年間有定期接受健康檢查者。代謝症候群組成包括了腹部肥胖（女性腰圍≥80公分，男性腰圍≥90公分）、高空腹血糖（≥100mg/dL）、高三酸甘油酯、高密度脂蛋白偏低及血壓偏高，此5項異常中符合3項者歸為代謝症候群發生。經追蹤4年後，研究對象之代謝症候群發生率為12.7%（男性為17.5%與女性為8.3%）。男性在50-59歲之前，代謝症候群發生率大於女性，但年齡增加後則反之，顯示更年期前女性受到保護。代謝異常發生以高空腹血糖、血壓偏高與高三酸甘油酯最多，特別在更年期後的女性。在男女性中，代謝症候群的發生與起始身體質量指數及年齡有顯著相關；而在男性中，抽菸也顯著與代謝症候群的發生有關。相對於僅注意代謝症候群及其組成盛行率，台灣更應提供預防代謝症候群發生的資訊及介入措施。
並列摘要
A large health screening program in Taiwan with members who have periodic checks provides an opportunity to track individuals who are healthy at baseline for the emergence of the metabolic syndrome (MS) and its component disorders. The syndrome comprised abdominal obesity assessed by waist circumference, high fasting serum glucose (FSG), high triglyceride (TG), low high density lipoprotein-cholesterol (HDL-C) and high blood pressure. A cohort of 9,785 adults (4,707 men and 5,078 women), aged 19 to 84 years, who were free from the MS at baseline were followed for 4 years from 1998 to 2002. Using Asian criteria for abdominal obesity and reducing the threshold for FSG from ≥110 mg/dL to ≥100 mg/dL, the incidence of MS during the 4-year follow up in the MJ Health Screening Center Study in Taiwan was 12.7% (17.5% for men and 8.3% for women). The incidence of the MS in men exceeded that for women up until 50-59 years and then this gender was reversed in the older age groups pointing to pre-menopausal protection in women. The most evident manifestations of the incident of metabolic abnormalities were high FSG, high blood pressure and high TG, particularly in post-menopausal women. Baseline body mass index and age were the most significant predictors of MS for both men and women, with cigarette smoking significantly predictive in men. Incident information should inform preventive and intervention strategies in Taiwanese, both Chinese and Indigenous, more effectively than MS and its component disorder prevalences.