Serum Vitamin D Status of Korean Postmenopausal Women during the Winter Months

韓國停經婦女在冬季的血清維生素D的狀態

Eun-Sil Lee ； Ji-Hyun Ahn ； Hyoung-Moo Park

《Asia Pacific Journal of Clinical Nutrition》 18卷1期 (2009/03) Pp. 29-33

https://doi.org/10.6133/apjcn.2009.18.1.05

摘要

目的：根據維生素D補充劑攝取量，探討韓國停經婦女在冬季的維生素D的狀態。研究設計：利用橫斷性研究，探討停經婦女中，攝取維生素D補充劑，血清25（OH）D的濃度。研究方法：2006年11月至2007年2月，本研究招募了254位到更年期門診而使用荷爾蒙療法，或使用骨質疏鬆症治療藥物的停經婦女。利用放射免疫分析試劑測量血清25（OH）D的濃度，並根據維生素D補充劑的攝取量去做分組比較。結果：25（OH）D的平均值為83.3±32.8nmol/L。隨著維生素D補充劑攝取提高，血清25（OH）D的濃度也增加。在第一組（沒有使用維生素D補充劑）和第二組（每日攝取100-300IU的維生素D補充劑）的25（OH）D平均值沒有顯著的差異。然而，第三組（每日攝取400IU的維生素D補充劑）的血清25（OH）D平均值顯著高於第一組。儘管第四組（每日攝取600IU的維生素D補充劑）的血清25（OH）D平均值沒有顯著不同於第三組，但顯著低於第五組（每日攝取800-900IU的維生素D補充劑）的25（OH）D平均值。結論：維生素D補充劑是非常有效地改善維生素D的狀態。比起以往的研究，本研究的族群之維生素D狀態有相當大的改善。因此，本篇推論停經婦女在大多數國家，包括韓國在內，維生素D缺乏的盛行應重新評估。

關鍵字

維生素D狀態 ； 韓國 ； 停經婦女 ； 冬季 ； 維生素D補充劑

並列摘要

Objective: To determine the vitamin D status of Korean postmenopausal women during the winter months according to the intake of vitamin D supplements. Design: Cross sectional study of serum 25(OH) D levels according to the intake of vitamin D supplements in postmenopausal women. Method: Between November 2006 and February 2007, 254 postmenopausal women who visited our menopausal clinic for hormone therapy or osteoporosis medication were recruited. Serum 25(OH)D levels were measured with a radioimmunoassay kit and the results were compared among groups that were classified according to the intake amount of vitamin D supplements. Results: The mean serum 25(OH)D level was 83.3 ± 32.8 nmol/L and it increased as the intake amount of vitamin D supplements increased. The mean serum 25(OH)D level was not significantly different between groups 1 (no vitamin D supplements) and 2 (daily 100-300 IU supplements). However, the mean serum 25(OH)D level was significantly higher in group 3 (daily 400 IU supplements) than in group 1. While the mean value of group 4 (daily 600 IU) was not significantly different from that of group 3, it was significantly lower than that of group 5 (daily 800-900 IU). Conclusion: Vitamin D supplementation is highly effective in improving vitamin D status and the vitamin D status in this study population was improved considerably when compared to previous studies. Therefore, it is concluded that the prevalence of vitamin D insufficiency should be re-evaluated in postmenopausal women in most countries including Korea.

並列關鍵字

vitamin D status ； Korea ； postmenopausal women ； winter ； vitamin D supplements