Levels of Insulin-Like Growth Factors and their Receptors in Placenta in Relation to Macrosomia

胎盘中的IGFs及其受体的表达水平与巨大儿关系的研究

Hua Jiang ； Peng-Cheng Xun ； Guang-Hua Luo ； Qiu-Wei Wang ； Yun-Qing Cai ； Ya-Ying Zhang ； Bin Yu

《Asia Pacific Journal of Clinical Nutrition》 18卷2期 (2009/06) Pp. 171-178

https://doi.org/10.6133/apjcn.2009.18.2.04

摘要

目的：研究足月胎盘中胰岛素样生长因子及其受体的mRNA的表达水平，與巨大儿发生风险的關聯。方法：从2008年3月1日至6月30日，在常州市妇幼保健院，收集足月分娩的37例巨大儿和37例正常体重儿的胎盘组织，采用Real Time PCR技术对胎盘中的胰岛素样生长因子及其受体的mRNA的表达水平进行检测。结果：在巨大儿组与对照组，胎盘的重量与新生儿出生体重均成正相关（r=0.550, p=0.004及r=0.678, p=0.000）。采用多因素非条件羅吉斯回归分析，在控制了混杂因素后，与最低IGF-II mRNA水平组相比，IGF-II mRNA中等水平组和高水平组发生巨大儿的OR值分别为17.3（95%CI: 2.50, 19.2）和5.94（95%CI: 0.96, 36.8）；而与最低IGF-IR mRNA水平组相比，中等水平组和高水平组IGF-IR mRNA发生巨大儿的OR值分别为25.3（95%CI: 3.43, 187）和43.0（95%CI: 4.89, 378）。结论：本研究显示胎盘中的IGF-II mRNA和IGF-IR mRNA的表达水平与巨大儿的发生可能有关。

關鍵字

巨大儿 ； 胎盘 ； 胰岛素样生长因子 ； 受体 ； 病例对照研究

並列摘要

Objective: To investigate the associations between mRNA levels that encodes for insulin-like growth factors (IGFS) and their receptors in term placenta, and the risk of macrosomia. Methods: Term placentas were collected from 37 neonates with macrosomia and 37 neonates with normal birth weight in Changzhou Women and Children Health Hospital from March 1 to June 30, 2008. The IGF mRNA levels and their receptors in those placentas were measured by Real-time PCR. Results: The placental weight was positively correlated with the birth weight both in the macrosomia group (r=0.550, p=0.004) and the control group (r=0.678, p=0.000). After adjusting for potential confounders, multivariable adjusted ORs of neonates with macrosomia for those in the increasing two tertiles were 17.3 (95%CI: 2.50-19.2) and 5.94 (95%CI: 0.96, 36.8), respectively, compared with those in the lowest tertile in terms of IGF-ⅡmRNA level. Similarly, multivariable adjusted ORs of neonates with macrosomia for those in the increasing two tertiles of IGF-ⅠR mRNA were 25.3 (95%CI: 3.43-187) and 43.0 (95%CI: 4.89, 378), respectively. Conclusion: These results indicate that the levels of placental IGF-Ⅱand IGF-ⅠR mRNA may be involved in the development of macrosomia.

並列關鍵字

macrosomia ； placenta ； insulin-like growth factor ； receptor ； case-control study