A Good Response to Oil with Medium-and Long-Chain Fatty Acids in Body Fat and Blood Lipid Profiles of Male Hypertriglyceridemic Subjects

中长链脂肪酸食用油可改善男性高甘油三酯血症患者体脂肪和血脂水平

Ying-Hua Liu ； Jin Wang ； Rong-Xin Zhang ； Yue-Hong Zhang ； Qing Xu ； Jie-Ying Zhang ； Yong Zhang ； Zi-Xin Zheng ； Xiao-Ming Yu ； Hong-Jiang Jing ； Naohisa Nosaka ； Michio Kasai ； Toshiaki Aoyama ； Jian Wu ； Chang-Yong Xue

《Asia Pacific Journal of Clinical Nutrition》 18卷3期 (2009/09) Pp. 351-358

https://doi.org/10.6133/apjcn.2009.18.3.07

摘要

采用双盲临床试验方法，将112名高甘油三酯血症患者随机分为中长链脂肪酸食用油组和长链脂肪酸食用油组，研究期限为8周。所有受试者控制每日膳食摄入量及食用油摄入量（25-30克／人／日），规定运动方式。分别于研究开始前和8周后对受试者进行人体組成测量及血生化指标检测。长链脂肪酸食用油组50例（男34例，女16例），中长链脂肪酸食用油组51例（男33例，女18例）完成了研究。男性中长链脂肪酸食用油组的体重、BMI、腰围、体脂肪重、腹部脂肪总面积、腹部皮下脂肪面积及血清甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B、C2、C3和E指标降低的程度明显大于长链脂肪酸食用油组。但这些指标在两组之间的女性患者没有发现显著性差异。因此，本研究表明男性高甘油三酯血症患者使用中长链脂肪酸食用油可减轻体重和体脂肪含量，改善血脂谱。

關鍵字

中链脂肪酸 ； 长链脂肪酸 ； 高甘油三酯血症 ； 性别 ； 中国人

並列摘要

A double blind clinical trial was carried out to clarify the effects of oil with medium- and long-chain triglyceride (MLCT) on body fat and blood lipid profiles in hypertriglyceridemic subjects. One-hundred-and-twelve subjects were enrolled and divided into two groups; those that consumed MLCT oil and those that consumed long-chain triglyceride (LCT) oil for 8 weeks. All subjects were requested to consume 25-30 g of the oils daily and maintain a fixed level of energy intake and exercise. Anthropometric and blood biochemical parameters were measured when the study was initiated and completed. The LCT group consisted of 50 subjects (34 men and 16 women), while the MLCT group consisted of 51 subjects (33 men and 18 women) who completed the study. Larger decreases in body weight, body mass index, waist circumference, body fat, total fat area and subcutaneous fat area in the abdomen and serum triglycerides, low-density lipoprotein cholesterol, apolipoprotein B, C2, C3 and E were observed in male subjects in the MLCT group than those in the LCT group. However, no significant differences in these parameters between the female subjects in the two groups were observed. Data from this study indicate that consumption of medium-and long-chain triglycerides can reduce body weight and body fat and improve blood lipid profiles in male hypertriglyceridemic subjects.

並列關鍵字

medium-chain fatty acids ； long-chain fatty acids ； hypertriglyceridemia ； sex ； Chinese