Comparison of Plasma and Intake Levels of Antioxidant Nutrients in Patients with Chronic Obstructive Pulmonary Disease and Healthy People in Taiwan: A Case-Control Study

探討台灣慢性阻塞性肺病患者血液及飲食中的抗氧化營養素含量：病例對照研究

Yi-Chin Lin ； Tzu-Chin Wu ； Pei-Ying Chen ； Li-Yun Hsieh ； Shu-Lan Yeh

《Asia Pacific Journal of Clinical Nutrition》 19卷3期 (2010/09) Pp. 393-401

https://doi.org/10.6133/apjcn.2010.19.3.14

摘要

氧化物／抗氧化物間的不平衡在慢性阻塞性肺病（COPD）的疾病發展上扮演著重要的角色。越來越多的證據顯示，血液或膳食中抗氧化營養素濃度較高的個體，可能維持有較好的肺功能。本研究的目的是探討台灣COPD病患血液及飲食中的抗氧化營養素含量是否較健康人低，以及COPD患者的飲食習慣是否影響其維生素C及各種類胡蘿蔔素的攝取量。研究中招募了34名COPD病患及43名肺功能正常的健康人（年齡≧50歲）參與試驗。收集受試者血液樣本，分析血漿維生素A、C、E以及類胡蘿蔔素濃度，並且分析白血球的內生性及H2O2誘發的DNA傷害（氧化壓力指標）。受試者維生素C及類胡蘿蔔素之膳食攝取量則以食物頻率問卷來分析。結果顯示，與健康對照組相比，COPD患者血漿中維生素A、C、E、α-和β-胡蘿蔔素及總類胡蘿蔔素的濃度均顯著較低，但白血球內生性及H2O2誘發的DNA傷害則顯著較高。COPD患者維生素C及數種類胡蘿蔔素的攝取量較健康者低，此外COPD患者蔬菜水果攝取量亦顯著較低。總結而言，本研究結果顯示，台灣COPD患者血漿及膳食中抗氧化營養素含量比健康人低，其維生素C及類胡蘿蔔素攝取量與飲食習慣具相關性。

關鍵字

慢性阻塞性肺病 ； 抗氧化物質 ； 台灣 ； 水果 ； 蔬菜

並列摘要

The imbalance of oxidant/antioxidant plays an important role in the development of chronic obstructive pulmonary disease (COPD). There is increasing evidence that individuals with high antioxidative nutrient levels in the diet or in blood tend to maintain better lung function. This study was conducted to determine whether COPD patients in Taiwan have lower plasma concentrations of antioxidative nutrients than do healthy people, and whether the dietary habits of COPD patients in Taiwan affect their intake of vitamin C and carotenoids. Thirty-four COPD patients and 43 healthy persons (with normal lung function) aged 50 years or older were recruited. Fasting venous blood was collected to measure concentrations of vitamins A, C, and E and carotenoids. Endogenous and H2O2-induced additional DNA damage (markers of oxidative stress) in white blood cells were assayed. Dietary intakes of vitamin C and carotenoids were assessed by a food-frequency questionnaire. Compare to the healthy controls, COPD patients had significantly lower plasma concentrations of vitamins A, C, and E; α- and β-carotene; and total carotenoids but significantly higher endogenous and H2O2-induced white blood cell DNA damage. Intakes of vitamin C and several carotenoids were lower in the COPD group, and COPD patients consumed significantly fewer vegetables and fruits than did the healthy controls. In conclusion, COPD patients in Taiwan have lower levels of antioxidative nutrients in their plasma and diet than do healthy people. Intakes of vitamin C and carotenoids are correlated with dietary habits.

並列關鍵字

COPD ； antioxidants ； Taiwan ； fruit ； vegetable