Association between 24 Hour Urinary α-tocopherol Catabolite, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol Intake in Intervention and Cross-sectional Studies

24小時尿液α-生育醇代謝產物2,5,7,8-2,5,7,8-tertranetgyl-2 (2'carboxyethyl)-6-hydroxychroman(α-CEHC)與α-生育醇攝取之介入及橫斷研究之相關

Eri Imai ； Eri Imai ； Mitsue Sano ； Tsutomu Fukuwatari ； Katsumi Shibata

《Asia Pacific Journal of Clinical Nutrition》 20卷4期 (2011/12) Pp. 507-513

https://doi.org/10.6133/apjcn.2011.20.4.02

摘要

The objective is to determine the association between the 24 hour urinary α-tocopherol catabolite, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol intake in an intervention and a cross-sectional studies. In the 4-weeks intervention study, Japanese men (n = 10) consumed the test diet in week 1, and the test diet plus varying amounts of α-tocopherol in the three subsequent weeks: 21 μmol/d α-tocopherol in week 2, 63 μmol/d in week 3, and 125 μmol/d in week 4. A significant association between α-tocopherol intake and urinary α-CEHC was observed in this strictly controlled experiment (r = 0.99, p＜0.001). In the crosssectional study, all foods consumed over 4 consecutive days were recorded in 76 free-living young subjects (18- 33 years). The association was weak, but a significant relationship was observed (r = 0.29, p＜0.05) even in the cross-sectional study. In the cross-sectional study adults, mean estimated α-tocopherol intake calculated by urinary α-CEHC and the excretory ratio was 91% of their mean intake over the 4 days. The results show that urinary α-CEHC level reflected recent α-tocopherol intake in free-living young Japanese adults, and could be used as a measure of intake during the previous few days, both for group means and for individual rankings within a group.

關鍵字

α-生育醇 ； 代謝產物 ； 尿液 ； 生物標記

並列摘要

The objective is to determine the association between the 24 hour urinary α-tocopherol catabolite, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol intake in an intervention and a cross-sectional studies. In the 4-weeks intervention study, Japanese men (n = 10) consumed the test diet in week 1, and the test diet plus varying amounts of α-tocopherol in the three subsequent weeks: 21 μmol/d α-tocopherol in week 2, 63 μmol/d in week 3, and 125 μmol/d in week 4. A significant association between α-tocopherol intake and urinary α-CEHC was observed in this strictly controlled experiment (r = 0.99, p＜0.001). In the crosssectional study, all foods consumed over 4 consecutive days were recorded in 76 free-living young subjects (18- 33 years). The association was weak, but a significant relationship was observed (r = 0.29, p＜0.05) even in the cross-sectional study. In the cross-sectional study adults, mean estimated α-tocopherol intake calculated by urinary α-CEHC and the excretory ratio was 91% of their mean intake over the 4 days. The results show that urinary α-CEHC level reflected recent α-tocopherol intake in free-living young Japanese adults, and could be used as a measure of intake during the previous few days, both for group means and for individual rankings within a group.

並列關鍵字

α-tocopherol ； catabolism ； CEHC ； urine ； biomarker