- 期刊
Age- and Gender-specific Associations between Low Serum 25-hydroxyvitamin D Level and Type 2 Diabetes in the Korean General Population: Analysis of 2008-2009 Korean National Health and Nutrition Examination Survey Data
韓國人民之低血清25-羥基維生素D濃度和第2型糖尿病在不同年齡及性別之相關性：2008-2009韓國國民健康營養調查之分析
摘要
前言：我們呈現的資料是來自2008-2009韓國國民健康營養調查，針對韓國成年人中一群具代表性樣本，探討25-羥基維生素D(25(OH)D)狀況和第2型糖尿病之相關性。方法：本篇研究是根據2008-2009 韓國國民健康營養調查的資料，調查之執行於2007至2009共3年的時間，利用滾動式抽樣設計，為一個複雜、分層、多步驟、集束的調查，所得到的樣本是一個南韓具代表性非機構住民之群體。結果：由分析資料顯示，韓國人民之血清25(OH)D 濃度與第2型糖尿病呈負相關。尤其在年輕女性和老年男性，其低血清25(OH)D與第2型糖尿病發生率的增加有相關。本研究亦顯示，25(OH)D與禁食胰島素濃度和胰島素抗性有顯著負相關。結論：低25(OH)D濃度與第2型糖尿病在不同年齡、性別之相關性，可能受維生素D、性荷爾蒙濃度和第2型糖尿病之間的交互作用影響。總之，韓國人民之低25(OH)D濃度與第2型糖尿病之相關性在不同性別、年齡呈現不一樣的模式。
並列摘要
Introduction: We present data from the Korean National Health and Nutritional Examination Survey (KNHANES) 2008-2009 on the association between 25-hydroxyvitamin D[25(OH)D] status and type 2 diabetes in a representative sample of the adult Korean population. Methods: This study was based on data obtained from the KNHANES 2008-2009, which was conducted for 3 years (2007-2009) using a rolling sampling design that involved a complex, stratified, multistage, probability-cluster survey of a representative sample of the non-institutionalized civilian population of South Korea. Results: We showed that serum 25(OH)D concentration is inversely associated with type 2 diabetes in the Korean general population. In particular, low serum 25(OH)D concentration was associated with an increased prevalence of type 2 diabetes in young women and old men. The present study showed that 25(OH)D has a significant negative association with fasting insulin and insulin resistance. Conclusion: The age- and gender-specific association between low 25(OH)D level and type 2 diabetes may be related to interactions between vitamin D, sex hormone concentrations, and type 2 diabetes. In conclusion, we showed that low 25(OH)D concentration is associated with type 2 diabetes in the Korean general population in an age- and gender-specific pattern.