- 期刊
- Ahead-of-Print
Association of serum 25-hydroxyvitamin D with skeletal muscle mass and function in the elderly in urban north China
並列摘要
Background and Objectives: To investigate the association of serum 25-hydroxyvitamin D (25(OH)D) with skeletal muscle mass (SMM) and function among the elderly in an urban area in northern China. Methods and Study Design: A total of 912 participants (316 men, 596 women) aged more than 60 years from 4 communities in Beijing were enrolled. Serum concentrations of 25(OH)D were measured through radioimmunoassay. SMM was assessed through bioelectrical impendence analysis, whereas skeletal muscle function were assessed through grip strength and 4-m regular gait speed measurements. On the basis of expert consensus of the Asian Working Group for Sarcopenia, low muscle mass was defined as relative skeletal mass index (RSMI) ＜7.0 kg/m^2 for men and ＜5.7 kg/m^2 for women. A noncondition logistical regression model was employed to explore the association between vitamin D and both muscle mass and function. Results: Serum 25(OH)D was positively associated with grip strength (β=0.16, SE=0.05). The upper quartile of 25(OH)D was negatively associated with loss of grip strength (OR=0.05, 95% CI: 0.01–0.48) in men but not in women. No significant associations were noted between 25(OH)D and appendicular skeletal muscle mass, RSMI, and gait speed (p＞0.05). Conclusions: The present study demonstrated a positive association between vitamin D and skeletal muscle strength in elderly Chinese men but not women.
延伸閱讀
- Meng, L., Man, Q., Yuan, L., Shen, L., Li, W., Guo, G., Li, L., Jia, S., Gao, Y., Song, P., & Zhang, J. (2017). Serum 25-hydroxyvitamin D and elderly skeletal muscle mass and function in urban north China. Asia Pacific Journal of Clinical Nutrition, 26(5), 849-855. https://doi.org/10.6133/apjcn.072016.13
- Ding, L., Wang, C. C., Ma, H. L., Tian, Y. L., Lu, Y., & Pang, S. G. (2014). The Study of Serum Vitamin D and Insulin Resistance in Chinese Populations with Normal Glucose Tolerance. International Journal of Endocrinology, 2014(), 973-976-202. https://doi.org/10.1155/2014/870235
- Fu, Y. Q., Yang, H., Zheng, J. S., Zeng, X. Y., Zeng, W., Fan, Z. F., Chen, M., Wang, L., & Li, D. (2013). Positive association between metabolic syndrome and serum uric acid in Wuhan. Asia Pacific Journal of Clinical Nutrition, (), 1-20. https://doi.org/10.6133/apjcn.012016.06
- Fu, Y. Q., Yang, H., Zheng, J. S., Zeng, X. Y., Zeng, W., Fan, Z. F., Chen, M., Wang, L., & Li, D. (2017). Positive association between metabolic syndrome and serum uric acid in Wuhan. Asia Pacific Journal of Clinical Nutrition, 26(2), 343-350. https://doi.org/10.6133/apjcn.012016.06
- Lai, S. W., Li, T. C., Li, C. I., Tan, C. K., Ng, K. C., Lai, M. M., Lin, C. S., & Lin, C. C. (1999). Association between Serum Uric Acid and Cardiovascular Risk Factors among Elderly People in Taiwan. The Kaohsiung Journal of Medical Sciences, 15(12), 686-690. https://doi.org/10.6452/KJMS.199912.0686