Effect of Vitamin B_12 and N-3 Polyunsaturated Fatty Acids on Plasma Homocysteine, Ferritin, C-Reaction Protein, and Other Cardiovascular Risk Factors: a Randomized Controlled Trial

Tao Huang ； Kelei Li ； Sailimuhan Asimi ； Qi Chen ； Jinyan Huang ； Duo Li

《Asia Pacific Journal of Clinical Nutrition》 預刊文章 Pp. 1-15

https://doi.org/10.6133/apjcn.2015.24.3.19

並列摘要

Objectives: Vitamin B_12 and n-3 polyunsaturated fatty acids (PUFA) decrease blood homocysteine (Hcy) concentrations. However, the combined effect of these nutrients on Hcy and ferritin, and C-reactive protein is limited and inconclusive. The objective was to examine the synergistic effect of vitamin B_12 in combination of n-3 PUFA on plasma Hcy, ferritin, and other biochemical markers. Methods: In a randomized controlled trial, thirty eligible subjects were randomly divided into three groups, and assigned to receive 1000μg of vitamin B_12, 2g fish oil, or 1000μg vitamin B_12 and 2g fish oil, respectively, for 8 weeks. Plasma phospholipids (PL) fatty acids and biochemical markers were determined. This study was registered under ClinicalTrials.gov Identifier: NCT01762072. Results: Plasma PL 20:5n-3, 22:6n-3 and n-3 PUFA was increased after 4 and 8 week supplementation of fish oil, and vitamin B_12+fish oil. Plasma concentrations of triacylglycerol, uric acid, C-reactive protein, and ferritin were significantly decreased after 4 and 8 week supplementation of fish oil, and vitamin B_12+fish oil. In all groups, significant changes in plasma Hcy were observed during the study period. Vitamin B_12, fish oil, and vitamin B_12+fish oil supplementation lowered plasma Hcy concentrations by 22%, 19%, and 39%, respectively. Conclusions: The combination of vitamin B_12 and fish oil has a synergistic effect on lowering plasma concentrations of Hcy.

並列關鍵字

homocysteine ； vitamin B_12 ； fish oil ； ferritin ； C-reaction protein