Community and individual iodine status assessment in premenopausal women in Shanxi, China: repeated spot urine versus 24-hour urine

Xiaomin Jia ； Jie Liu ； Wenwen Gu ； Peng Zhang ； Wendi Liu ； Hong Zhu ； Xiaotong Liu ； Maocheng Sang ； Jiawen Ding ； Zhongna Sang

《Asia Pacific Journal of Clinical Nutrition》 預刊文章 Pp. 1-15

https://doi.org/10.6133/apjcn.202010/PP.0001

摘要

Background and Objectives: Urinary iodine is an essential index of iodine nutrition evaluation. To establish the number of repeated spot urine collections necessary to reflect individual iodine status over 2 months and assess its feasibility to serve as an independent indicator of individual iodine status. Methods and Study Design: We performed a longitudinal, 2-months study from May to June in 2015 of 23 apparently healthy Chinese women aged 18 to 44 (32±9) y. Spot urine samples were collected on any two days of the week, and 24-h urine samples were collected once every 6 days. Results: 368 spot urine and 230 24-h urine samples were analysed. The median urinary iodine concentration (UIC) was 140.5 (75.2, 246.9) μg/L. The estimated 24-h urinary iodine excretion (24-h UIE) values from spot urine samples and measured 24-h UIE values from 24-h urine samples were 348±240μg/24h and 330±216μg/24h (p=0.003), respectively. Irrespective of the urinary iodine method, the intra-individual coefficient of variation (CV%) was lower than the inter-individual CV%. Bland-Altman analysis revealed differences between spot urine and 24-h urine. When the precision ranges with 95% confidence were ±15%, ±20%, ±25% or 30%, the number of an individual's spot urine samples required were 30, 16, 11 or 8, respectively. Conclusions: Repeated spot urine is not a feasible way to assess recent individual iodine intake. The development of a multi-indicator system could provide an acceptable individual evaluation index of iodine status.

關鍵字

iodine intake ； repeated spot urine samples ； UIC ； 24h-UIE ； individual iodine assessment