Efficacy and safety of parenteral nutrition with iron sucrose for anemia prevention in preterm infants: A randomized, double-blind controlled study

Qingqing Wu ； Ying Wang ； Weiping Wang ； Yonghong Zhang ； Weihui Yan ； Lina Lu ； Yijing Tao ； Qingya Tang

《Asia Pacific Journal of Clinical Nutrition》 預刊文章 Pp. 1-15

https://doi.org/10.6133/apjcn.202203/PP.0004

摘要

Background and Objectives: Our objective is to study the efficacy and safety of parenteral nutrition (PN) with iron sucrose to prevent anemia in preterm infants. Methods and Study Design: We performed a randomized, double-blind controlled trial in which preterm infants were divided into five groups randomly: a control group (PN without iron sucrose, namely group Iron-0), and intervention groups (PN with iron sucrose 100 μg/kg/d, 200 μg/kg/d, 300 μg/kg/d and 400 μg/kg/d, namely group Iron-1, 2, 3, and 4, respectively). The indicators were red blood cell (RBC) parameters, iron storage and oxidant stress. Results: One hundred infants completed this study. Excepting the RBC count in Iron-2, the value of erythrocyte parameters in intervention groups decreased less than that in the control group. And the decrease of RBC count in Iron-1 (-0.6×10^(12)/L vs -0.9×10^(12)/L, p=0.033), hemoglobin in Iron-4 (-26.0 g/L vs -41.0 g/L, p=0.03) and hematocrit in Iron-1(-9.5% vs -14.0%, p=0.014) was significantly less than in the control group. The change of ferritin in Iron-4 was significantly higher than in the control group (280.2 ng/ml vs 117.5 mg/ml, p=0.04). There was no difference in serum iron in intervention groups when compared to the control group (p＞0.05). Except for the change of Malondialdehyde (MDA) in Iron-1, the increase in other intervention groups was higher than in the control group (p＞0.05). Conclusions: PN with iron sucrose for prevention of anemia in preterm infants is safe and efficacious to some extent.

關鍵字

preterm infants ； anemia ； iron sucrose ； parenteral nutrition