Controlling nutritional score predict the individualized survival of patients with gastric cancer

Zhu Xishan ； Zhao Ye ； Ma Feiyan ； Wu Shikai

《Asia Pacific Journal of Clinical Nutrition》 預刊文章 Pp. 1-16+18-00670

https://doi.org/10.6133/apjcn.202101/PP.0008

摘要

Background and Objectives: The present study aimed to determine the correlation between controlling nutritional score (CONUT) and prognosis in gastric cancer patients undergoing total gastrectomy. Methods and Study Design: The clinical data of 245 gastric cancer patients who underwent total gastrectomy in Peking University, First Hospital between January1st 2005 and December 30th 2015 were retrospectively collected. According to the CONUT level, they were divided into high CONUT (＞3) group and low CONUT (≤3) group. The relationship between CONUT and the disease-free survival (DFS) and overall survival (OS) were analyzed by statistical analysis. Results: The results showed that the optimal cutoff value for CONUT to predict the 5-year survival was 3 and CONUT had a higher area under the ROC curve (AUC) for 5-year disease free survival (DFS) and overall survival (OS) prediction. Additionally, when age was considered as a stratified factor, univariate analyses demonstrated that high CONUT correlated with shorter DFS in non-elderly (＜65) patients and shorter DFS and OS in elderly (≥65) patients. Conclusions: High CONUT was significantly correlated with older age, advanced TNM-stage, higher Ki-67 and pathological subtype. Patients with high pre-operative high CONUT levels should be given more observation and constant follow-up after surgery.

關鍵字

controlling nutritional score (CONUT) ； gastric cancer ； disease-free survival (DFS) ； overall survival (OS) ； cancer prognosis