Low Physical Activity and Energy Dense Malaysian Foods are Associated with Non-Alcoholic Fatty Liver Disease in Centrally Obese but not in Non-Centrally Obese Patients with Diabetes Mellitus

Wah-Kheong Chan, MBBS, MRCP1, Alexander Tong-Boon Tan, MBChB, MRCP2, Shireene Ratna\dVethakkan, MBBS, MMed, MD2, Pei-Chien Tah, BSc, MSc3, Anushya Vijayananthan,MBBS,MRad4,\dKhean-Lee Goh, MBBS, FRCP, MD1

《Asia Pacific Journal of Clinical Nutrition》 預刊文章 Pp. 1-16

https://doi.org/10.6133/apjcn.2015.24.2.15

並列摘要

Objective: To study the dietary intake and level of physical activity (PA) of patients with diabetes mellitus and the association with non-alcoholic fatty liver disease (NAFLD). Methods: Consecutive adult patients with type 2 diabetes mellitus seen in our hospital diabetes clinic were enrolled. The Global Physical Activity Questionnaire and a semiquantitative food-frequency questionnaire were used to assess PA and dietary intake, respectively. Diagnosis of NAFLD was ultrasound-based and following exclusion of significant alcohol intake and other causes of chronic liver disease. Results: Data for 299 patients were analyzed (mean age 63.3±10.5 years old, 41.1% male). Prevalence of NAFLD was 49.2%. Patients with low PA were more likely to have NAFLD (OR=1.75, 95% CI=1.03-2.99, p=0.029). There was no significant difference in energy intake, intake of macronutrients and percentage energy intake from each macronutrient, high sugar food, high cholesterol food and high SFA food between patients with and without NAFLD. Among centrally obese patients, patients with low PA and in the highest quartile of percentage energy intake from fat (OR=4.03, 95% CI=1.12-15.0, p=0.015), high cholesterol food (OR=3.61, 95% CI=1.37-9.72, p=0.004) and high SFA food (OR=2.67, 95% CI=1.08-6.67, p=0.019) were most likely to have NAFLD. Among those who were not centrally obese, PA and percentage energy intake from fat, high cholesterol food and high SFA food was not associated with NAFLD. Conclusion: Low PA and high percentage energy intake from fat, high cholesterol food and high SFA food is associated with NAFLD in centrally obese but not in non-centrally obese patients with diabetes mellitus.

並列關鍵字

diet ； physical activity ； non-alcoholic fatty liver disease ； diabetes mellitus ； obesity