- 期刊
- Ahead-of-Print
Dietary glycemic load and metabolic status in newly diagnosed type 2 diabetes in southeastern China
摘要
Background and Objectives: Large-scale epidemiological investigations worldwide have shown that dietary glycemic load is associated with several metabolic diseases, including diabetes. However, only a few studies have examined the correlations between dietary glycemic load and blood glucose and lipid concentrations in Chinese patients with diabetes. Therefore, this study aimed to determine these correlations in patients with newly diagnosed type 2 diabetes in southeastern China. Methods and Study Design: 201 patients with newly diagnosed type 2 diabetes and 126 participants with normal blood glucose concentrations were enrolled at the Sun Yat-sen University, Sun Yat-sen Memorial Hospital, Guangdong Province. Carbohydrate intake and glycemic load were assessed based on 3-day dietary records. Using glycemic load as the dependent variable, a correlation analysis and multiple regression analyses were used to analyze the correlations between dietary glycemic load and blood glucose and lipid concentrations. Results: The mean dietary glycemic load in patients with newly diagnosed type 2 diabetes was significantly higher than that in participants with normal blood glucose concentrations (p＜0.05). The correlation analysis showed that dietary glycemic load was positively correlated with body mass index and glycated hemoglobin in patients with diabetes (p＜0.05) but negatively correlated with high-density lipoprotein cholesterol in both the control and diabetes groups (p＜0.05). Multivariable regression analysis indicated that, among participants in southeastern China, a higher glycemic load increased the odds of having diabetes, a low high-density lipoprotein cholesterol concentration, and higher Charlson weighted index of comorbidities score, as well as being overweight. Conclusion: A high-glycemic load diet may be associated with a risk of diabetes, glycemic control, lipid metabolism, prognosis of diseases, and body composition. It is necessary to control dietary glycemic load for both patients with diabetes and healthy people in southeastern China.
延伸閱讀
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