Nutrition Assessment and Its Relationship with Performance and Glasgow Prognostic Scores in Vietnamese Patients with Esophageal Cancer

Tran Chau Quyen ； Jongjit Angkatavanich ； Jongjit Angkatavanich ； Vo Van Xuan ； Le Danh Tuyen ； Do Anh Tu

《Asia Pacific Journal of Clinical Nutrition》 預刊文章 Pp. 1-21

https://doi.org/10.6133/apjcn.122015.02

並列摘要

Objectives: To determine the nutritional status of patients with esophageal cancer, and to investigate its relationship with performance status and prognosis. Participants and methods: This clinical, cross-sectional study was conducted from August 2014 to February 2015 at National Cancer Hospital, Hanoi, Vietnam. Stage III/IV esophageal cancer patients were assessed for their nutritional status (patient-generated subjective global assessment (PG-SGA) and SGA scores, BMI, mid-arm circumference (MAC), energy and protein intakes, weight changes, Karnofsky and Eastern cooperative oncology group performance scores (KPS/ECOG), and Glasgow prognostic score (GPS). Results: Sixty-four male patients were enrolled. The mean standard deviation of PG-SGA score was 9.88 ± 4.41. SGA revealed forty-four% as class B and 6.2% as class C. The BMI revealed 43.8% of patients were underweight. MAC measurement revealed 29.7% of undernourished patients. Patients with an energy intake ＜25 kcal/kg/d comprised 54.7%, and 48.4% with ＜1 g/kg/day of protein. Totally, 68.8%, 84.4% and 92.2% patients exhibited weight loss past 2-weeks, one-month and six-months, respectively. The PG-SGA and Skewered strongly correlated with the KPS (r=-0.717 and 0.632, both p＜0.001) and ECOG (r=0.672 and 0.626, both p＜0.001), but were weakly correlated with the GPS (r=0.332 and 0.278, p＜0.01 and 0.05). The KPS, ECOG, BMI, MAC, energy and protein intakes, and weight change were not correlated with the GPS. Conclusions: Malnutrition, weight change, and insufficient intake were noteworthy in esophageal cancer patients. The PG-SGA and SGA were strongly correlated with the performance status, but weakly correlated with prognostic indices.

並列關鍵字

esophageal cancer ； nutritional status ； performance score ； prognostic score ； weight loss