Reducing Effect of Calcium in Combination with Magnesium and Lactulose on Body Fat Mass in Middle-Aged Japanese Women

日本中年女性攝取鈣質結合鎂及乳果糖對體脂肪量的降低效果

Nobuo Seki ； Yuzou Asano ； Hiroshi Ochi ； Fumiaki Abe ； Kazuhiro Uenishi ； Hideki Kudou

《Asia Pacific Journal of Clinical Nutrition》 預刊文章 Pp. 29-36

摘要

背景：關於足夠的鈣質攝取可降低體脂肪及適量的鎂攝取可阻斷代謝症候群的發展已有報告。此外，乳果糖可增加鈣及鎂的吸收。因此，鈣、鎂及乳果糖的最佳組合或可降低體脂肪量。方法：以開放式隨機控制實驗測試含300 mg鈣、150 mg鎂及4.0 g乳果糖的食物對體脂肪降低的效果。在基線、6個月及12個月後，分別測量體組成參數、血液中數種激素及尿中礦物質量。以雙能量X光吸收儀測量全身體脂肪量。結果：76名中年日本女性（47.5 ± 4.7歲）被隨機分派為攝取組（n＝48）或是非攝取控制組（n＝28）。儘管兩組的體位測量值沒有差異，但在12個月後，兩組體脂肪改變量的差異（攝取組－控制組）為-0.8公斤（95％CI：-1.5－0.0公斤，p＝0.046）。攝取組在12個月的體脂肪百分比傾向較低，但是這個差異不顯著（p＝0.09）。結論：這些發現顯示鈣質結合鎂及乳果糖或可以降低日本中年女性的體脂肪量。然而，在這個研究中，鎂及乳果糖的貢獻並不清楚。需要更進一步的研究去釐清這些效益。

關鍵字

鈣 ； 鎂 ； 乳果糖 ； 體脂肪量 ； 日本女性

並列摘要

Background: It has been reported that adequate calcium intake decreases body fat and appropriate intakes of magnesium suppress the development of the metabolic syndrome. Furthermore, lactulose increases the absorption of calcium and magnesium. An optimal combination of calcium, magnesium and lactulose may therefore reduce body fat mass. Methods: An open-label randomized controlled trial was conducted to investigate the body fat-reducing effects of a test food containing 300 mg calcium, 150 mg magnesium, and 4.0 g lactulose. Body composition parameters and blood hormone and urine mineral concentrations were measured at baseline and at 6 and 12 months thereafter. Whole-body fat mass was measured with dual-energy x-ray absorptiometry. Results: Seventy-six middle-aged Japanese women (47.5 ± 4.7 years) were randomized to the intake group (n = 48) or the non-intake control group (n = 28). At 12 months the difference in body fat mass change between the two groups (intake group-control group) was -0.8 kg (95% CI: -1.5-0.0 kg, p = 0.046), although there were no differences in anthropometric data between the two groups. Body fat percentage at 12 months tended to be lower in the intake group, but the difference was not significant (p = 0.09). Conclusions: These findings may suggest that calcium in combination with magnesium and lactulose can reduce body fat mass in middle-aged Japanese women. However, the contribution of magnesium and lactulose are unclear in this study. Further studies are needed to clarify these contributions.

並列關鍵字

calcium ； magnesium ； lactulose ； fat mass ； Japanese women