Effect of vitamin B-12 and n-3 polyunsaturated fatty acids on plasma homocysteine, ferritin, C-reactive protein, and other cardiovascular risk factors: a randomized controlled trial

维生素B-12和欧米伽3多不饱和脂肪酸对血浆同型半胱氨酸、铁蛋白、C反应蛋白和其它心血管危险因素的影响：一项随机对照临床试验

Tao Huang ； Kelei Li ； Sailimuhan Asimi ； Qi Chen ； Duo Li

《Asia Pacific Journal of Clinical Nutrition》 24卷3期 (2015/09) Pp. 403-411

https://doi.org/10.6133/apjcn.2015.24.3.19

摘要

目的：维生素B-12和欧米伽3多不饱和脂肪酸能够降低血液同型半胱氨酸浓度。但是，这两种营养元素是否对同型半胱氨酸、铁蛋白、C反应蛋白有协同效应仍不清楚。方法：为进一步解决该问题，我们开展了一项随机对照实验，38位参与者随机分为三组，每天分别食用1000 μg维生素B-12、2 g鱼油、1000 μg维生素B-12 + 2 g鱼油。八周以后，收集受试者血样，测定血浆磷脂脂肪酸组成，生物标志物等。结果：四周或者八周干预以后，鱼油组和鱼油+维生素B-12组的血浆磷脂20 : 5n-3、22 : 6n-3 和总欧米伽3脂肪酸显著升高，然而，血浆甘油三酯、尿酸、C反应蛋白以及铁蛋白显著降低。维生素B-12组、鱼油组、维生素B-12 +鱼油组，血浆同型半胱氨酸分别降低22%、19%和39%。结论：维生素B-12和鱼油在调节同型半胱氨酸代谢过程中存在协同效应。

關鍵字

同型半胱氨酸 ； 维生素B-12 ； 鱼油 ； 铁蛋白 ； C反应蛋白

並列摘要

Objectives: Vitamin B-12 and n-3 polyunsaturated fatty acids (PUFA) decrease blood homocysteine (Hcy) concentrations. However, the combined effect of these nutrients on Hcy and ferritin, and C-reactive protein is limited and inconclusive. The objective was to examine the synergistic effect of vitamin B-12 in combination of n-3 PUFA on plasma Hcy, ferritin, and other biochemical markers. Methods: In a randomized controlled trial, thirty eligible subjects were randomly divided into three groups, and assigned to receive 1000 μg of vitamin B-12, 2 g fish oil, or 1000 μg vitamin B-12 and 2 g fish oil, respectively, for 8 weeks. Plasma phospholipids (PL) fatty acids and biochemical markers were determined. This study was registered under ClinicalTrials.gov Identifier: NCT01762072. Results: Plasma PL 20:5n-3, 22:6n-3 and n-3 PUFA was increased after 4 and 8 week supplementation of fish oil, and vitamin B-12 + fish oil. Plasma concentrations of triacylglycerol, uric acid, C-reactive protein, and ferritin were significantly decreased after 4 and 8 week supplementation of fish oil, and vitamin B- 12 + fish oil. In all groups, significant changes in plasma Hcy were observed during the study period. Vitamin B- 12, fish oil, and vitamin B-12+fish oil supplementation lowered plasma Hcy concentrations by 22%, 19%, and 39%, respectively. Conclusions: The combination of vitamin B-12 and fish oil has a synergistic effect on lowering plasma concentrations of Hcy.

並列關鍵字

Homocysteine ； vitamin B-12 ； fish oil, ferritin ； C-reactive protein