- 期刊
Metabolic syndrome and risks of carotid atherosclerosis and cardiovascular events in community-based older adults in China
摘要
Background and Objectives: Previous studies on the importance of metabolic syndrome (MS) as a cardiovascular risk factor had not focused on older Chinese adults. The present study analyzed the association of MS with carotid atherosclerosis and the risk of cardiovascular events in Chinese adults. Methods and Study Design: Data of a representative cohort study with 5-year follow-up were used. Community-dwelling people (n=1257) aged ≥55 years without cardiovascular disease (CVD) at baseline were followed up from 2009 to 2014. MS was defined based on the Chinese Diabetes Society criteria under the Chinese Medical Association. Multiple regression analyses were performed to examine the associations of MS with atherosclerosis and CVD events, with adjustment for confounding factors. Results: In a multivariate logistic regression model with adjustment, MS was closely related to common carotid artery intima-media thickness (CCA-IMT) (1.62; 95% CI: 1.19-2.21) and carotid plaque presence (1.38; 95% CI: 1.01-1.89), but not with carotid artery stenosis. At the end of the 5-year follow-up, compared with subjects without MS, hazard ratios and 95% confidence intervals for the different risks in subjects with MS were 1.86 (1.02-3.29) for myocardial infarction (MI), 1.39 (1.01-2.05) for stroke, 1.52 (1.02-2.37) for CVD death, and 1.13 (0.62-2.58) for total death, after adjusting for age, gender, smoking, drinking, physical activity, uric acid, high-sensitivity C-reactive protein, dietary factors and carotid atherosclerosis status. Conclusions: MS was significantly associated with IMT and the presence of carotid plaque and with positively increased risks of MI, stroke, and CVD mortality independent of CVD risk factors in older Chinese adults.
延伸閱讀
- Ma, Y., Su, C., Wang, H., Wang, Z., Liang, H., & Zhang, B. (2013). Relationship between carbohydrate intake and risk factors for cardiovascular disease in Chinese adults: data from the China Health and Nutrition Survey (CHNS). Asia Pacific Journal of Clinical Nutrition, (), 1-21. https://doi.org/10.6133/apjcn.201906/PP.0005
- Ma, Y., Su, C., Wang, H., Wang, Z., Liang, H., & Zhang, B. (2019). Relationship between carbohydrate intake and risk factors for cardiovascular disease in Chinese adults: data from the China Health and Nutrition Survey (CHNS). Asia Pacific Journal of Clinical Nutrition, 28(3), 520-532. https://doi.org/10.6133/apjcn.201909_28(3).0011
- 陳信豪、蔡思盈、黃秀梨（2022）。The Influences of Metabolic Health Status and Body Weight on Cardiovascular Events and All-cause Mortality in the Elderly: a Representative Cohort Study in Taiwan。台灣老年醫學暨老年學會雜誌，17(1)，46-59。https://doi.org/10.29461/TGGa.202202_17(1).0004
- Yao, M. F., He, J., Sun, X., Ji, X. L., Ding, Y., Zhao, Y. M., Lou, H. Y., Song, X. X., Shan, L. Z., Kang, Y. X., Zhang, S. Z., & Shan, P. F. (2016). Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China. International Journal of Endocrinology, 2016(), 284-290-132. https://doi.org/10.1155/2016/8483405
- Kozlov, S., Balachonova, T., Machmudova, H., Tripoten, M., Andreevskaya, M., Rogoza, A., & Kuharchuk, V. (2012). Carotid Atherosclerosis, Endothelial Disfunction, and Arterial Stiffness in Young and Middle-Aged Men with Coronary Artery Disease. International Journal of Vascular Medicine, 2012(), 533-537. https://doi.org/10.1155/2012/950130