Chlorogenic acid intake guidance: Sources, health benefits, and safety

Yingxiang Yu ； Zhida Zhang ； Cuiqing Chang

《Asia Pacific Journal of Clinical Nutrition》 31卷4期 (2022/12) Pp. 602-610

https://doi.org/10.6133/apjcn.202212_31(4).0003

摘要

Chlorogenic acid (CGA) is widely present in plant foods and has attracted much attention due to biological activities such as those which are antioxidant, anti-inflammatory, antibacterial, and antiviral. It plays a role in regulating glucose and lipid metabolism, improving insulin resistance, and reducing the risk of type 2 diabetes and cardiovascular diseases. The estimated dietary intake of CGA is 5 to 1000 mg/d. Based on the data from population intervention studies, daily oral doses of CGA at 13.5mg to 1200 mg can reduce fasting blood glucose (FBG), improve glucose tolerance, enable weight loss /prevent weight gain, and improve blood pressure in hypertensive patients. Daily intake of 200 mg or more may reduce FBG, with a dose-effect relationship in the range 13.5-500 mg/d. Therefore, a specific proposed level (SPL) of CGA to improve FBG could be ≥200 mg/d. Data insufficiency does not allow formulation of a tolerable upper intake level (TUIL) for CGA.

關鍵字

chlorogenic acid ； acyl quinic acid ； caffeoylquinic acid ； specific proposed level ； tolerable upper intake level