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Objectives: For African American girls, the research questions were: 1) Do body fat, maturity, and physical activity predict blood pressure values? 2) Do body fat, maturity, and psychosocial and environmental variables predict physical activity? 3) Do maturity and physical activity predict body fat? Methods: The design was a four year observational study and measures were taken twice a year. The anthropometric measures and interviews were completed by trained staff. Results: Moderate-to-vigorous physical activity decreased and sedentary behavior increased over time. Age, body mass index, and height were significant predictors of systolic blood pressure. Height was the only significant predictor of diastolic blood pressure. Age (negative relationship), cognitive and social factors were significant predictors of moderate-to-vigorous physical activity. Age and maturity (more advanced breast stages) were significant predictors of body mass index. Conclusions: Promoting healthy lifestyles in adolescent, African American girls should include preventing the decline in physical activity by developing positive social networks.

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