The present study was designed to investigate the relationship of anxiety with achievement of high school students and also to see the regional and gender differences on the basis of their anxiety. The study was conducted over a sample of 400 (200 boys and 200 girls) high school students studying in Xth class in 8 different schools (4 urban and 4 rural) affiliated to CBSE, New Delhi. Sharma's general anxiety scale for children was used to measure anxiety and the aggregate score of the selected students in the board examinations was taken to show their level of achievement. The results reported that there exists a negative and significant relationship between anxiety and achievement. Significant differences were observed between boys and girls, rural and urban students on the basis of their anxiety.